Background: Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy. Objectives: The validation of novel (chemo)preventive and interceptive approaches, and the use of new or repurposed agents, alone or in combination with registered drugs, are urgently required. Results: Phytochemicals (triterpenoids, flavonoids, retinoids) and their derivatives, nonsteroidal anti-inflammatory drugs (aspirin) as well as biguanides (metformin and phenformin) originally developed from phytochemical backbones, are multi-target agents showing antiangiogenic and anti-anti-inflammatory proprieties. Many of them target AMPK and metabolic pathways such as the mTOR axis. We summarize the beneficial effects of several compounds in conferring protection and supporting therapy, and as a paradigm, we present data on terpenoids & biquanides on beer hop xanthohumol and hydroxytryrosol from olive mill waste waters. Conclusions: These molecules could be employed for combinatorial chemoprevention and interception approaches or chemoprevention/therapy regimens for cancer and other chronic complex diseases.

Nutraceuticals and “repurposed” drugs of phytochemical origin in prevention and interception of chronic degenerative diseases and cancer

Bassani B.;Baci D.;Gallazzi M.;Bruno A.;Noonan D. M.
2019

Abstract

Background: Chronic, degenerative diseases are often characterized by inflammation and aberrant angiogenesis. For these pathologies, including rheumatoid arthritis, cardiovascular and autoimmune diseases, cancer, diabetes, and obesity, current therapies have limited efficacy. Objectives: The validation of novel (chemo)preventive and interceptive approaches, and the use of new or repurposed agents, alone or in combination with registered drugs, are urgently required. Results: Phytochemicals (triterpenoids, flavonoids, retinoids) and their derivatives, nonsteroidal anti-inflammatory drugs (aspirin) as well as biguanides (metformin and phenformin) originally developed from phytochemical backbones, are multi-target agents showing antiangiogenic and anti-anti-inflammatory proprieties. Many of them target AMPK and metabolic pathways such as the mTOR axis. We summarize the beneficial effects of several compounds in conferring protection and supporting therapy, and as a paradigm, we present data on terpenoids & biquanides on beer hop xanthohumol and hydroxytryrosol from olive mill waste waters. Conclusions: These molecules could be employed for combinatorial chemoprevention and interception approaches or chemoprevention/therapy regimens for cancer and other chronic complex diseases.
http://www.eurekaselect.com/CDN/download.php?param=Sk9ViUk5qBTFCMvQqkVO3L0NkNQyr8yNEi82oLzAlwMDiZDLjnBkzZnxo8YX7BwbzGljcYXRqpb2a4vcsGRm3fHxkjNToY4ZfjY4lOWMB1NjgU0Ynjcx7M2UpyYz4djNEWQ4kZDAe2MDpYwMDwTcVYTcVYp&key=VWlxmRWlquZEiUtQcVNEzc2RsZZk3VJQsTMy5RDMl1Rjuc1NeDV2lLTQs3MzlItMajM18NjQqzMjmNERh2VEceATcVYeTcVY
Aberrant angiogenesis; Cancer; CD; Nutraceuticals; Phytochemical drugs; Repurposed drugs; Chronic Disease; Humans; Neoplasms; Neurodegenerative Diseases; Dietary Supplements; Drug Repositioning
Albini, A.; Bassani, B.; Baci, D.; Dallaglio, K.; Gallazzi, M.; Corradino, P.; Bruno, A.; Noonan, D. M.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/2086444
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