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Background
Acute appendicitis is the most common surgical emergency in children. Differentiation of acute appendicitis from conditions that do not require operative management can be challenging in children. This study aimed to identify the optimum risk prediction model to stratify acute appendicitis risk in children.
Methods
We did a rapid review to identify acute appendicitis risk prediction models. A prospective, multicentre cohort study was then done to evaluate performance of these models. Children (aged 5–15 years) presenting with acute right iliac fossa pain in the UK and Ireland were included. For each model, score cutoff thresholds were systematically varied to identify the best achievable specificity while maintaining a failure rate (ie, proportion of patients identified as low risk who had acute appendicitis) less than 5%. The normal appendicectomy rate was the proportion of resected appendixes found to be normal on histopathological examination.
Findings
15 risk prediction models were identified that could be assessed. The cohort study enrolled 1827 children from 139 centres, of whom 630 (34·5%) underwent appendicectomy. The normal appendicectomy rate was 15·9% (100 of 630 patients). The Shera score was the best performing model, with an area under the curve of 0·84 (95% CI 0·82–0·86). Applying score cutoffs of 3 points or lower for children aged 5–10 years and girls aged 11–15 years, and 2 points or lower for boys aged 11–15 years, the failure rate was 3·3% (95% CI 2·0–5·2; 18 of 539 patients), specificity was 44·3% (95% CI 41·4–47·2; 521 of 1176), and positive predictive value was 41·4% (38·5–44·4; 463 of 1118). Positive predictive value for the Shera score with a cutoff of 6 points or lower (72·6%, 67·4–77·4) was similar to that of ultrasound scan (75·0%, 65·3–83·1).
Interpretation
The Shera score has the potential to identify a large group of children at low risk of acute appendicitis who could be considered for early discharge. Risk scoring does not identify children who should proceed directly to surgery. Medium-risk and high-risk children should undergo routine preoperative ultrasound imaging by operators trained to assess for acute appendicitis, and MRI or low-dose CT if uncertainty remains.
Funding
None.
Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study.
Dmitri Nepogodiev;Richard Jw Wilkin;Catherine J Bradshaw;Clare Skerritt;Alasdair Ball;Waaka Moni-Nwinia;Ruth Blanco-Colino;Priyesh Chauhan;Thomas M Drake;Matteo Frasson;Oliver Gee;James C Glasbey;Jacob H Matthews;Gabriella L Morley;David N Naumann;Francesco Pata;Antonio S Soares;Aneel Bhangu;S H Abbas;A M Abdelgadir;A Abdelrahman;M Abdelrahman;A Abdelwahed;Y Abou El Ella;M Abulafi;A Acharya;M E Adam;R E Adams;S O Adegbola;A Adimonye;M Adnan;S Afshar;A Ahad;J Ahel;D P Ahern;A Ahmad Asmadi;B Ahmed;G Ahmed;O S Ahmed;S Ahmed;K Akbari;O Akinsola;W Al-Khyatt;B Al-Sarireh;M Al-Sheikh;M Alani;R Alexander;T Alhammali;M Ali;A Aljorfi;M Allen;J Allington;A Alshafei;R Amarasinghe;A Amayo;V Amin;Thuva Amuthalingam;L Anandan;O Anderson;S M Andreani;B Andrews;A Ang;B Aravind;J E Archer;M A Aremu;S Arunachalam;N Aruparayil;D L Ashmore;O Ashour;N Ashraf;N Assaf;H Avalapati;O O Awokoya;J Ayube-Brown;T Badenoch;R Bagga;A Baginski;S Bailey;Str Bailey;C Baird;B Baker;E J Balai;A Balasubramaniam;S K Bandyopadhyay;A Banks;H Bansal;W Barnieh;A Barrie;C A Barter;J Bastianpillai;W D Beasley;C R Bell;J Bell;D Beral;Bjm Berry;K E Bevan;V Bevan;Shiv Bhanderi;A Bhargava;D Bilku;A Birindelli;O D Blackford;Jem Blackwell;L Blake;Natalie S Blencowe;T D Boam;C Boereboom;M Bogdan;P Bohra;J C Bolger;W Bolton;S Bond;C M Borg;K Borghol;P R Boshier;N Bouhadiba;J Bowen;H Bowerman;C R Bowman;H Boyd-Carson;C J Bradshaw;G Branagan;P Brennan;M Brett;H K Brewer;H Brewer;C Bronder;A Brown;A G Brown;C E Brown;M Brown;R Brown;S Buckley-Jones;A Budzanowski;W Bukhari;C Bull;J K Bullivant;K M Burns;D Burnside;A Busuttil;B E Byrne;C K Byrnes;M Caldwell;R Callan;F C Cameron;U Campbell;U M Campbell;W Campbell;C A Carden;Cfw Carder;K Carney;H Cartwright;P Cay;A Chalk;B Chambers;A Champsi;D Chan;Tcw Chan;S B Chandler;J Chapman;A Charalabopoulos;B Chasty;M Chatzikonstantinou;W L Cheah;C S Chean;S Cheng;S A Cheng;M Cheruvu;M Y Chin;I A Chishti;S Choi;S M Chok;B Chong;J H Choong;M Chowdhary;F Chowdhury;C H Choy;L Christian;P Christopoulos;K Chui;M Cipparrone;G L Clark;S A Clarke;S J Cleeve;K D Clement;B Clements;C Clements;J D Clements;J M Clements;J S Clements;J A Clements;R Clingan;L Cloney;Ecs Clough;P O Coe;O Collier-Wakefield;D W Colliver;D A Colvin;T M Connelly;M J Connor;V Cook;F Cooke;F Cooper;A E Cotton;D G Couch;L Cousins;D Coyle;W Creasy;R L Cresner;A Crone;K Cross;J Crozier;P Cunha;N J Curtis;N D'Souza;H Dagash;S Dalmia;I Daniels;D Danquah-Boateng;F A Dar;K Dart;A Das;R Daureeawoo;S Davidson;J R Davidson;P L Davies;S Davis;V Daya Shetty;A De-Manzoni-Garberini;J A De-Marchi;E A Dean;S Dean;C Delimpalta;S Denley;G Dennison;A A Devine;S Dharamavaram;A A Dhari;F Di Franco;Salomone Di Saverio;C Dobson;J A Docherty;C Doherty;G Donaldson;N O Donohoe;O Donohoe;E Douka;T Doulias;M Downey;C Doyle;N Drye;D T Du;J G Dudek;P G Dunning;Ars Dyal;N J Eardley;L Earnshaw;S Easdon;S E Edwards;R J Egan;R J Egan;S El-Masry;O El-Tayar;C R Elbourne;S Elgaddal;M Elseedawy;M Elshaer;O H Elsharnoby;Wma Elzeneini;K M Emslie;Nft Engall;B Ertansel;H D Esmail;C Ettles;J Evans;J D Evans;A Everden;M Fadel;S E Fahmy;C J Fairfield;B F Fanibi;Valeria Farina;S M Farrell;E Z Farrow;J A Fasuyi;G Faulkner;D Fawkner-Corbett;F Fawzi;M Fehervari;N Ferguson;J G Finch;H Finlayson;T Flack;W Foers;N M Foley;K Ford;A Forgie;A Foster;J D Foster;Amw Fox;N Francis;D Franklin;H Froud;H L Fuller;E Gaines;J Galea;E Gammeri;J Garnham;J Garvin;Z Gates;R Gentry;I Ghaffari;S Ghatorae;A L Gidwani;T G Gilbert;T M Gilbert;S Gill;M Gillespie;J Gillick;A Giorga;K Gopalakrishnan;S Gopalswamy;S Gopinath;R Gormely;G Govind;C Grant;J Graveston;J Gray;R T Gray;D Griffith;J P Griffith;Ewen A Griffiths;S N Griffiths;E J Griggs;S Grosvenor;T Grove;M Gulamhussein;J Guliani;A Gummaraju;S Gunning;S V Gurjar;S Guru-Naidu;S Gurung;H Habib;L Hackney;James B Haddow;S Hajibandeh;C Halkias;N J Hall;R N Hamelmann;M Haneef;M S Haneef;Z Hanif;C Hanley;A J Hann;T Hanna;E Hardy;A Harlinska;F Harper;R L Harries;A Harris;Grant Harris;M P Harris;R Hasan;A Hassane;J R Hatt;Z Haveliwala;W Hawkins;Z Hayat;C Hayes;Krm Hebbar;L Henderson;L T Henderson;Pjj Herrod;P Hever;L M Hickey;G Hicks;J M Hodgson;M Hoff;A Hollingsworth;A Hook;S T Hornby;E Horsfield;E E Howie;L Huang;N J Hudson-Peacock;D L Hughes;K A Hureibi;A Hussain;N Hussain;S A Hussaini;A Hussein;B Hutchinson;Yms Ibrahim;S Ikram;T Ilozue;E Iosif;M R Iqbal;S Irukulla;R Irwin;N Islam;P Ivey;C R Jackson;A Jackson;Smh Jah;A Jain;S Jain;Sarus Jain;G M Jama;N B Jamieson;S Janardanan;B Jasinski;D Jenner;E Jerome;B Johnson;A Johnstone;S Jokhan;A Jones;C E Jones;C S Jones;E Jones;L Jones;U Kabir;S Kabwama;M Kamal;I W Kamande;V Kanakala;M Kannegieser-Bailey;S Kaptanis;M J Karim;R S Karwal;G Kaur;R Keegan;A Kelay;N D Kennedy;D A Kent;A Khair;K Khan;S Khan;A Khasria;H Kho;J Kilkenny;R King;J Kinross;E N Kirkham;B Knight;R Kochupapy;C Koh;O Kouli;A Krishnamoorthy;S Krivan;K Kumar;S Kumar;Vws Kung;R Kuo;G Lafaurie;C W Lai;N Lal;S Lawday;S Layman;G R Layton;A Lazzaro;L 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Sezen;P Sgardelis;A Sgrò;C Shah;J Shah;K Shah;S M Shah;Z Shakoor;M S Shalaby;V Shanmuganathan;K Shanmugarajah;A Sharma;P Sharma;A Sharma;O L Sharp;J A Shepherd;M A Sherif;S Shet;G Shingler;M H Shiwani;D Shreshta;T Sian;M N Siddiqui;Z A Siddiqui;K L Siggens;N Sihra;I Silva;A Simioni;Lfc Simmonds;D J Simpson;A Singh;S Singh;T Singhal;P Sivaloganathan;K Sloan;N Smallcombe;C J Smart;Neil J Smart;R Smith;H Smoker;L Solinas;Jeh Souter;E L Springate;G F Stephens;R Stevenson;D J Stewart;I Stoica;E Strachan;B M Stubbs;W Stupalkowska;A Suliman;A Sultana;H Sunter;S Suriyakumar;Nra Symons;K Szentpali;A Szucs;V Tabain;L E Tague;K Tailor;C Y Tan;S Tan;A M Tang;M Tarazi;Y H Tay;S Tayeh;M Taylor;N S Taylor;D Taze;E Teasdale;N Thakral;B Thava;N Thavanesan;A J Thaventhiran;K Theodoropoulou;A T Thomas;L Thomas;D B Thompson;R Thompson;S N Thoukididou;S G Tiboni;L A Tiedt;N Ting;B J Tinsley;J M Tognarelli;J Torkington;A Torrance;D C Townsend;P J Tozer;M Trail;F Trew;V Tudyka;L Tullie;A Turnbull;E J Turner;C S Twum-Barima;Robert Tyler;S Vakis;A La Valle;G I Van Boxel;J Vance-Daniel;M Varcada;N Varma;E M Vaughan;V R Velchuru;R Velho;A K Venkatasubramaniam;M L Venn;V Vijay;Z Vinnicombe;P Vitish-Sharma;S Wagener;K Waite;K J Walters;U Walters;B G Wardle;S D Wardle;J Warusavitarne;J Watfah;N Watson;J Wauchope;L W Weatherburn;C R Weegenaar;S Welsh;S Wheatstone;H E Whewell;P Whitehouse;E Whiteman;L Whittaker;K Wijesundera;D Wilkinson;G L Williams;M Williams;R Williams;S Williams;E J Wilson;Msj Wilson;D C Winter;G Winter;J Wolff;A Wong;Cll Wong;S Y Wong;C S Wood;C Woodrow;A Woodward;B Woodward;E Wright;H L Wright;F Wu;S Yalamarthi;P Yang;E Yardimci;T Yasin;S K Yen;S Yoganathan;S Yoong;H Youssef;Lps Yow;A Zaborowski;A Z Zadi;Z A Zarka;M A Zarog;A Y Zhang;Aneel Bhangu
2020-01-01
Abstract
Background
Acute appendicitis is the most common surgical emergency in children. Differentiation of acute appendicitis from conditions that do not require operative management can be challenging in children. This study aimed to identify the optimum risk prediction model to stratify acute appendicitis risk in children.
Methods
We did a rapid review to identify acute appendicitis risk prediction models. A prospective, multicentre cohort study was then done to evaluate performance of these models. Children (aged 5–15 years) presenting with acute right iliac fossa pain in the UK and Ireland were included. For each model, score cutoff thresholds were systematically varied to identify the best achievable specificity while maintaining a failure rate (ie, proportion of patients identified as low risk who had acute appendicitis) less than 5%. The normal appendicectomy rate was the proportion of resected appendixes found to be normal on histopathological examination.
Findings
15 risk prediction models were identified that could be assessed. The cohort study enrolled 1827 children from 139 centres, of whom 630 (34·5%) underwent appendicectomy. The normal appendicectomy rate was 15·9% (100 of 630 patients). The Shera score was the best performing model, with an area under the curve of 0·84 (95% CI 0·82–0·86). Applying score cutoffs of 3 points or lower for children aged 5–10 years and girls aged 11–15 years, and 2 points or lower for boys aged 11–15 years, the failure rate was 3·3% (95% CI 2·0–5·2; 18 of 539 patients), specificity was 44·3% (95% CI 41·4–47·2; 521 of 1176), and positive predictive value was 41·4% (38·5–44·4; 463 of 1118). Positive predictive value for the Shera score with a cutoff of 6 points or lower (72·6%, 67·4–77·4) was similar to that of ultrasound scan (75·0%, 65·3–83·1).
Interpretation
The Shera score has the potential to identify a large group of children at low risk of acute appendicitis who could be considered for early discharge. Risk scoring does not identify children who should proceed directly to surgery. Medium-risk and high-risk children should undergo routine preoperative ultrasound imaging by operators trained to assess for acute appendicitis, and MRI or low-dose CT if uncertainty remains.
Funding
None.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2094558
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Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
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