A sequence of seven reactions (stereocontrolled allylation, Mitsunobu reaction, ring closing metathesis, and amino/amido intramolecular nucleophilic addition) efficiently convert the inexpensive starting 2-piperidine ethanol into a small library of enatiomerically pure nitrogen containing compounds characterized by three new scaffolds that present a relevant diversity. This simple approach encroaches the further exploration of the chemical space.

Stereodivergent Diversity-Oriented Synthesis: Exploiting the Versatility of 2-Piperidine Ethanol

Foschi F.;Sironi M.;
2019-01-01

Abstract

A sequence of seven reactions (stereocontrolled allylation, Mitsunobu reaction, ring closing metathesis, and amino/amido intramolecular nucleophilic addition) efficiently convert the inexpensive starting 2-piperidine ethanol into a small library of enatiomerically pure nitrogen containing compounds characterized by three new scaffolds that present a relevant diversity. This simple approach encroaches the further exploration of the chemical space.
2019
2-Piperidine ethanol; Diversity-oriented synthesis; Piperidine alkaloids; Piperidine derivatives; Stereodivergent synthesis
Bonandi, E.; Marzullo, P.; Foschi, F.; Perdicchia, D.; Presti, L. L.; Sironi, M.; Pieraccini, S.; Gambacorta, G.; Saupe, J.; Dalla Via, L.; Passarella...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2095412
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