Preliminary studies suggested that drug-related toxicity of sunitinib may correlate with a better prognosis. We conducted a retrospective multicenter study regarding sunitinib-related toxicity. We evaluated 145 patients with metastatic renal cancer treated with sunitinib in first-line therapy. At univariate and multivariate analysis, we observed a protective effect of hypertension and neutropenia on tumor progression.
On-target Toxicities Predictive of Survival in Metastatic Renal Cell Carcinoma (mRCC) Treated With Sunitinib: A Multicenter Retrospective Study
Bolzacchini E.;Pinotti G.;Verusio C.;Mumoli N.;Rossini C.;Barzaghi S.;Ballerio A.;Dentali F.
2020-01-01
Abstract
Preliminary studies suggested that drug-related toxicity of sunitinib may correlate with a better prognosis. We conducted a retrospective multicenter study regarding sunitinib-related toxicity. We evaluated 145 patients with metastatic renal cancer treated with sunitinib in first-line therapy. At univariate and multivariate analysis, we observed a protective effect of hypertension and neutropenia on tumor progression.
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