Introduction: Immune reconstitution after stem cell transplantation (SCT) plays a crucial role in host defense against microbial agents. The thymus atrophy occurring with ageing represents a limit for de novo T-cell reconstitution, although the reactivation of thymic function after BMT is documented. The proper strategy to improve the thymic output is currently matter of debate. Pre-clinical and clinical evidences suggest that Zinc oral supplementation may contribute to thymic reactivation and to improve the T-mediated cellular defense against pathogens. We tested the role of Zinc oral supplementation in immune reconstitution, using as model the autologous SCT in multiple myeloma.

Zinc Oral Supplementation Induces a Significant Rise of TRECs and T CD4+NaiVe and Prevents the Increase of Ttv Viral Load after Stem Cell Transplantation: The Zenith Study

Fabrizio Maggi;
2016

Abstract

Introduction: Immune reconstitution after stem cell transplantation (SCT) plays a crucial role in host defense against microbial agents. The thymus atrophy occurring with ageing represents a limit for de novo T-cell reconstitution, although the reactivation of thymic function after BMT is documented. The proper strategy to improve the thymic output is currently matter of debate. Pre-clinical and clinical evidences suggest that Zinc oral supplementation may contribute to thymic reactivation and to improve the T-mediated cellular defense against pathogens. We tested the role of Zinc oral supplementation in immune reconstitution, using as model the autologous SCT in multiple myeloma.
L, Iovino; Orciuolo, Enrico; Buda, Gabriele; Carulli, Giovanni; Maggi, Fabrizio; Focosi, Daniele; Morganti, Riccardo; Guerrini, Francesca; Galimberti, Sara; Petrini, Mario
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/2102297
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