Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such as respiratory syncytial virus pneumonia and Ebolavirus disease. In the ongoing COVID-19 pandemic, early signals of efficacy from convalescent plasma therapy have encouraged research and development of anti-SARS-CoV-2 mAbs. While many candidates are in preclinical development, we focus here on anti-SARS-CoV-2 neutralizing mAbs (or mAb cocktails) that represent the late-stage clinical pipeline, i.e., those currently in Phase 2 or Phase 3 clinical trials. We describe the structure, mechanism of action, and ongoing trials for VIR-7831, LY-CoV555, LY-CoV016, BGB-DXP593, REGN-COV2, and CT-P59. We speculate also on the next generation of these mAbs.

Anti-SARS-CoV-2 neutralizing monoclonal antibodies: clinical pipeline

Maggi F.
Penultimo
;
2020-01-01

Abstract

Monoclonal antibody (mAb) therapy has been previously exploited for viral infections, such as respiratory syncytial virus pneumonia and Ebolavirus disease. In the ongoing COVID-19 pandemic, early signals of efficacy from convalescent plasma therapy have encouraged research and development of anti-SARS-CoV-2 mAbs. While many candidates are in preclinical development, we focus here on anti-SARS-CoV-2 neutralizing mAbs (or mAb cocktails) that represent the late-stage clinical pipeline, i.e., those currently in Phase 2 or Phase 3 clinical trials. We describe the structure, mechanism of action, and ongoing trials for VIR-7831, LY-CoV555, LY-CoV016, BGB-DXP593, REGN-COV2, and CT-P59. We speculate also on the next generation of these mAbs.
bamlanivimab; BGB-DXP593; COVID-19; CT-P59; GSK4182136; LY-CoV016; LY-CoV555; monoclonal antibody; REGN-COV2; SARS-CoV-2; VIR-7831; Antibodies, Monoclonal; Antibodies, Neutralizing; Antibodies, Viral; COVID-19; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Humans; Immunization, Passive; SARS-CoV-2
Tuccori, M.; Ferraro, S.; Convertino, I.; Cappello, E.; Valdiserra, G.; Blandizzi, C.; Maggi, F.; Focosi, D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2104062
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