The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

Mazzinari, G.; Serpa Neto, A.; Hemmes, S. N. T.; Hedenstierna, G.; Jaber, S.; Hiesmayr, M.; Hollmann, M. W.; Mills, G. H.; Vidal Melo, M. F.; Pearse, R. M.; Putensen, C.; Schmid, W.; Severgnini, P.; Wrigge, H.; Cambronero, O. D.; Ball, L.; de Abreu, M. G.; Pelosi, P.; Schultz, M. J.; Kroell, W.; Metzler, H.; Struber, G.; Wegscheider, T.; Gombotz, H.; Urbanek, B.; Kahn, D.; Momeni, M.; Pospiech, A.; Lois, F.; Forget, P.; Grosu, I.; Poelaert, J.; van Mossevelde, V.; van Malderen, M. -C.; Dylst, D.; van Melkebeek, J.; Beran, M.; de Hert, S.; De Baerdemaeker, L.; Heyse, B.; Van Limmen, J.; Wyffels, P.; Jacobs, T.; Roels, N.; De Bruyne, A.; van de Velde, S.; Leva, B.; Damster, S.; Plichon, B.; Juros-Zovko, M.; Djonovic-Omanovic, D.; Pernar, S.; Zunic, J.; Miskovic, P.; Zilic, A.; Kvolik, S.; Ivic, D.; Azenic-Venzera, D.; Skiljic, S.; Vinkovic, H.; Oputric, I.; Juricic, K.; Frkovic, V.; Kopic, J.; Mirkovic, I.; Karanovic, N.; Carev, M.; Dropulic, N.; Saric, J. P.; Erceg, G.; Dvorscak, M. B.; Mazul-Sunko, B.; Pavicic, A. M.; Goranovic, T.; Maldini, B.; Radocaj, T.; Gavranovic, Z.; Mladic-Batinica, I.; Sehovic, M.; Stourac, P.; Harazim, H.; Smekalova, O.; Kosinova, M.; Kolacek, T.; Hudacek, K.; Drab, M.; Brujevic, J.; Vitkova, K.; Jirmanova, K.; Volfova, I.; Dzurnakova, P.; Liskova, K.; Dudas, R.; Filipsky, R.; el Kafrawy, S.; Abdelwahab, H. H.; Metwally, T.; Abdel-Razek, A.; El-Shaarawy, A. M.; Hasan, W. F.; Ahmed, A. G.; Yassin, H.; Magdy, M.; Abdelhady, M.; Mahran, M.; Herodes, E.; Kivik, P.; Oganjan, J.; Aun, A.; Sormus, A.; Sarapuu, K.; Mall, M.; Karjagin, J.; Futier, E.; Petit, A.; Gerard, A.; Marret, E.; Solier, M.; Prades, A.; Krassler, J.; Merzky, S.; de Abreu, M. G.; Uhlig, C.; Kiss, T.; Bundy, A.; Bluth, T.; Gueldner, A.; Spieth, P.; Scharffenberg, M.; Thiem, D. T.; Koch, T.; Treschan, T.; Schaefer, M.; Bastin, B.; Geib, J.; Weiss, M.; Kienbaum, P.; Pannen, B.; Gottschalk, A.; Konrad, M.; Westerheide, D.; Schwerdtfeger, B.; Simon, P.; Reske, A.; Nestler, C.; Valsamidis, D.; Stroumpoulis, K.; Antholopoulos, G.; Andreou, A.; Karapanos, D.; Theodoraki, K.; Gkiokas, G.; Tasoulis, M. -K.; Sidiropoulou, T.; Zafeiropoulou, F.; Florou, P.; Pandazi, A.; Tsaousi, G.; Nouris, C.; Pourzitaki, C.; Bystritski, D.; Pizov, R.; Eden, A.; Pesce, C. V.; Campanile, A.; Marrella, A.; Grasso, S.; De Michele, M.; Bona, F.; Giacoletto, G.; Sardo, E.; Giancarlo, L.; Sottosanti, V.; Solca, M.; Volta, C. A.; Spadaro, S.; Verri, M.; Ragazzi, R.; Zoppellari, R.; Cinnella, G.; Raimondo, P.; La Bella, D.; Mirabella, L.; D'Antini, D.; Molin, A.; Brunetti, I.; Gratarola, A.; Pellerano, G.; Sileo, R.; Pezzatto, S.; Montagnani, L.; Pasin, L.; Landoni, G.; Zangrillo, A.; Beretta, L.; Di Parma, A. L.; Tarzia, V.; Dossi, R.; Sassone, M. E.; Sances, D.; Tredici, S.; Spano, G.; Castellani, G.; Delunas, L.; Peradze, S.; Venturino, M.; Arpino, I.; Sher, S.; Tommasino, C.; Rapido, F.; Morelli, P.; Vargas, M.; Servillo, G.; Cortegiani, A.; Raineri, S. M.; Montalto, F.; Russotto, V.; Giarratano, A.; Baciarello, M.; Generali, M.; Cerati, G.; Leykin, Y.; Bressan, F.; Bartolini, V.; Zamidei, L.; Brazzi, L.; Liperi, C.; Sales, G.; Pistidda, L.; Brugnoni, E.; Musella, G.; Bacuzzi, A.; Muhardri, D.; Gecaj-Gashi, A.; Sada, F.; Bytyqi, A.; Karbonskiene, A.; Aukstakalniene, R.; Teberaite, Z.; Salciute, E.; Tikuisis, R.; Miliauskas, P.; Jurate, S.; Kontrimaviciute, E.; Tomkute, G.; Xuereb, J.; Bezzina, M.; Borg, F. J.; Hemmes, S.; Hollmann, M.; Wiersma, I.; Binnekade, J.; Bos, L.; Boer, C.; Duvekot, A.; in 't Veld, B.; Werger, A.; Dennesen, P.; Severijns, C.; De Jong, J.; Hering, J.; van Beek, R.; Ivars, S.; Jammer, I.; Breidablik, A.; Hodt, K. S.; Fjellanger, F.; Avalos, M. V.; Mellin-Olsen, J.; Andersson, E.; Shafi-Kabiri, A.; Molina, R.; Wutai, S.; Morais, E.; Tareco, G.; Ferreira, D.; Amaral, J.; de Lurdes Goncalves Castro, M.; Cadilha, S.; Appleton, S.; Parente, S.; Correia, M.; Martins, D.; Monteirosa, A.; Ricardo, A.; Rodrigues, S.; Horhota, L.; Grintescu, I. M.; Mirea, L.; Grintescu, I. C.; Corneci, D.; Negoita, S.; Dutu, M.; Garotescu, I. P.; Filipescu, D.; Prodan, A. B.; Droc, G.; Fota, R.; Popescu, M.; Tomescu, D.; Petcu, A. M.; Tudoroiu, M. I.; Moise, A.; Guran, C. -T.; Gherghina, I.; Costea, D.; Cindea, I.; Copotoiu, S. -M.; Copotoiu, R.; Barsan, V.; Tolcser, Z.; Riciu, M.; Moldovan, S. G.; Veres, M.; Gritsan, A.; Kapkan, T.; Gritsan, G.; Korolkov, O.; Kulikov, A.; Lubnin, A.; Ovezov, A.; Prokoshev, P.; Lugovoy, A.; Anipchenko, N.; Babayants, A.; Komissarova, I.; Zalina, K.; Likhvantsev, V.; Fedorov, S.; Lazukic, A.; Pejakovic, J.; Mihajlovic, D.; Kusnierikova, Z.; Zelinkova, M.; Bruncakova, K.; Polakovicova, L.; Sobona, V.; Novak-Supe, B.; Pekle-Golez, A.; Jovanov, M.; Strazisar, B.; Markovic-Bozic, J.; Novak-Jankovic, V.; Voje, M.; Grynyuk, A.; Kostadinov, I.; Spindler-Vesel, A.; Moral, V.; Unzueta, M. C.; Puigbo, C.; Fava, J.; Canet, J.; Moret, E.; Rodriguez Nunez, M.; Sendra, M.; Brunelli, A.; Rodenas, F.; Monedero, P.; Martinez, F. H.; Temino, M. J. Y.; Martinez Simon, A.; de Abajo Larriba, A.; Lisi, A.; Perez, G.; Martinez, R.; Granell, M.; Vivo, J. T.; Ruiz, C. S.; de Andres Ibanez, J. A.; Pastor, E.; Soro, M.; Ferrando, C.; Defez, M.; Alvares-Santullano, C. A.; Perez, R.; Rico, J.; Jawad, M.; Saeed, Y.; Gillberg, L.; Bengisun, Z. K.; Kazbek, B. K.; Coskunfirat, N.; Boztug, N.; Sanli, S.; Yilmaz, M.; Hadimioglu, N.; Senturk, N. M.; Camci, E.; Kucukgoncu, S.; Sungur, Z.; Sivrikoz, N.; Ozgen, S. U.; Toraman, F.; Selvi, O.; Senturk, O.; Yildiz, M.; Kuvaki, B.; Gunenc, F.; Kucukguclu, S.; Ozbilgin, S.; Maral, J.; Canli, S.; Arun, O.; Saltali, A.; Aydogan, E.; Akgun, F. N.; Sanlikarip, C.; Karaman, F. M.; Mazur, A.; Vorotyntsev, S.; Rousseau, G.; Barrett, C.; Stancombe, L.; Shelley, B.; Scholes, H.; Limb, J.; Rafi, A.; Wayman, L.; Deane, J.; Rogerson, D.; Williams, J.; Yates, S.; Rogers, E.; Pulletz, M.; Moreton, S.; Jones, S.; Venkatesh, S.; Burton, M.; Brown, L.; Goodall, C.; Rucklidge, M.; Fuller, D.; Nadolski, M.; Kusre, S.; Lundberg, M.; Everett, L.; Nutt, H.; Zuleika, M.; Carvalho, P.; Clements, D.; Creagh-Brown, B.; Watt, P.; Raymode, P.; Pearse, R.; Mohr, O.; Raj, A.; Creary, T.; Chishti, A.; Bell, A.; Higham, C.; Cain, A.; Gibb, S.; Mowat, S.; Franklin, D.; West, C.; Minto, G.; Boyd, N.; Mills, G.; Calton, E.; Walker, R.; Mackenzie, F.; Ellison, B.; Roberts, H.; Chikungwa, M.; Jackson, C.; Donovan, A.; Foot, J.; Homan, E.; Montgomery, J.; Portch, D.; Mercer, P.; Palmer, J.; Paddle, J.; Fouracres, A.; Datson, A.; Andrew, A.; Welch, L.; Rose, A.; Varma, S.; Simeson, K.; Rambhatla, M.; Susarla, J.; Marri, S.; Kodaganallur, K.; Das, A.; Algarsamy, S.; Colley, J.; Davies, S.; Szewczyk, M.; Smith, T.; Fernandez-Bustamante, A.; Luzier, E.; Almagro, A.; Melo, M. V.; Fernando, L.; Sulemanji, D.; Sprung, J.; Weingarten, T.; Kor, D.; Scavonetto, F.; Tze, Y.

doi:10.1186/s12871-021-01268-y

Background: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods: Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. Results: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12– to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001). Conclusions: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. Trial registration: LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223).

The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

Mazzinari G.;Serpa Neto A.;Hemmes S. N. T.;Hedenstierna G.;Jaber S.;Hiesmayr M.;Hollmann M. W.;Mills G. H.;Vidal Melo M. F.;Pearse R. M.;Putensen C.;Schmid W.;Severgnini P.;Wrigge H.;Cambronero O. D.;Ball L.;de Abreu M. G.;Pelosi P.;Schultz M. J.;Kroell W.;Metzler H.;Struber G.;Wegscheider T.;Gombotz H.;Urbanek B.;Kahn D.;Momeni M.;Pospiech A.;Lois F.;Forget P.;Grosu I.;Poelaert J.;van Mossevelde V.;van Malderen M. -C.;Dylst D.;van Melkebeek J.;Beran M.;de Hert S.;De Baerdemaeker L.;Heyse B.;Van Limmen J.;Wyffels P.;Jacobs T.;Roels N.;De Bruyne A.;van de Velde S.;Leva B.;Damster S.;Plichon B.;Juros-Zovko M.;Djonovic-Omanovic D.;Pernar S.;Zunic J.;Miskovic P.;Zilic A.;Kvolik S.;Ivic D.;Azenic-Venzera D.;Skiljic S.;Vinkovic H.;Oputric I.;Juricic K.;Frkovic V.;Kopic J.;Mirkovic I.;Karanovic N.;Carev M.;Dropulic N.;Saric J. P.;Erceg G.;Dvorscak M. B.;Mazul-Sunko B.;Pavicic A. M.;Goranovic T.;Maldini B.;Radocaj T.;Gavranovic Z.;Mladic-Batinica I.;Sehovic M.;Stourac P.;Harazim H.;Smekalova O.;Kosinova M.;Kolacek T.;Hudacek K.;Drab M.;Brujevic J.;Vitkova K.;Jirmanova K.;Volfova I.;Dzurnakova P.;Liskova K.;Dudas R.;Filipsky R.;el Kafrawy S.;Abdelwahab H. H.;Metwally T.;Abdel-Razek A.;El-Shaarawy A. M.;Hasan W. F.;Ahmed A. G.;Yassin H.;Magdy M.;Abdelhady M.;Mahran M.;Herodes E.;Kivik P.;Oganjan J.;Aun A.;Sormus A.;Sarapuu K.;Mall M.;Karjagin J.;Futier E.;Petit A.;Gerard A.;Marret E.;Solier M.;Prades A.;Krassler J.;Merzky S.;de Abreu M. G.;Uhlig C.;Kiss T.;Bundy A.;Bluth T.;Gueldner A.;Spieth P.;Scharffenberg M.;Thiem D. T.;Koch T.;Treschan T.;Schaefer M.;Bastin B.;Geib J.;Weiss M.;Kienbaum P.;Pannen B.;Gottschalk A.;Konrad M.;Westerheide D.;Schwerdtfeger B.;Simon P.;Reske A.;Nestler C.;Valsamidis D.;Stroumpoulis K.;Antholopoulos G.;Andreou A.;Karapanos D.;Theodoraki K.;Gkiokas G.;Tasoulis M. -K.;Sidiropoulou T.;Zafeiropoulou F.;Florou P.;Pandazi A.;Tsaousi G.;Nouris C.;Pourzitaki C.;Bystritski D.;Pizov R.;Eden A.;Pesce C. V.;Campanile A.;Marrella A.;Grasso S.;De Michele M.;Bona F.;Giacoletto G.;Sardo E.;Giancarlo L.;Sottosanti V.;Solca M.;Volta C. A.;Spadaro S.;Verri M.;Ragazzi R.;Zoppellari R.;Cinnella G.;Raimondo P.;La Bella D.;Mirabella L.;D'antini D.;Molin A.;Brunetti I.;Gratarola A.;Pellerano G.;Sileo R.;Pezzatto S.;Montagnani L.;Pasin L.;Landoni G.;Zangrillo A.;Beretta L.;Di Parma A. L.;Tarzia V.;Dossi R.;Sassone M. E.;Sances D.;Tredici S.;Spano G.;Castellani G.;Delunas L.;Peradze S.;Venturino M.;Arpino I.;Sher S.;Tommasino C.;Rapido F.;Morelli P.;Vargas M.;Servillo G.;Cortegiani A.;Raineri S. M.;Montalto F.;Russotto V.;Giarratano A.;Baciarello M.;Generali M.;Cerati G.;Leykin Y.;Bressan F.;Bartolini V.;Zamidei L.;Brazzi L.;Liperi C.;Sales G.;Pistidda L.;Brugnoni E.;Musella G.;Bacuzzi A.;Muhardri D.;Gecaj-Gashi A.;Sada F.;Bytyqi A.;Karbonskiene A.;Aukstakalniene R.;Teberaite Z.;Salciute E.;Tikuisis R.;Miliauskas P.;Jurate S.;Kontrimaviciute E.;Tomkute G.;Xuereb J.;Bezzina M.;Borg F. J.;Hemmes S.;Hollmann M.;Wiersma I.;Binnekade J.;Bos L.;Boer C.;Duvekot A.;in 't Veld B.;Werger A.;Dennesen P.;Severijns C.;De Jong J.;Hering J.;van Beek R.;Ivars S.;Jammer I.;Breidablik A.;Hodt K. S.;Fjellanger F.;Avalos M. V.;Mellin-Olsen J.;Andersson E.;Shafi-Kabiri A.;Molina R.;Wutai S.;Morais E.;Tareco G.;Ferreira D.;Amaral J.;de Lurdes Goncalves Castro M.;Cadilha S.;Appleton S.;Parente S.;Correia M.;Martins D.;Monteirosa A.;Ricardo A.;Rodrigues S.;Horhota L.;Grintescu I. M.;Mirea L.;Grintescu I. C.;Corneci D.;Negoita S.;Dutu M.;Garotescu I. P.;Filipescu D.;Prodan A. B.;Droc G.;Fota R.;Popescu M.;Tomescu D.;Petcu A. M.;Tudoroiu M. I.;Moise A.;Guran C. -T.;Gherghina I.;Costea D.;Cindea I.;Copotoiu S. -M.;Copotoiu R.;Barsan V.;Tolcser Z.;Riciu M.;Moldovan S. G.;Veres M.;Gritsan A.;Kapkan T.;Gritsan G.;Korolkov O.;Kulikov A.;Lubnin A.;Ovezov A.;Prokoshev P.;Lugovoy A.;Anipchenko N.;Babayants A.;Komissarova I.;Zalina K.;Likhvantsev V.;Fedorov S.;Lazukic A.;Pejakovic J.;Mihajlovic D.;Kusnierikova Z.;Zelinkova M.;Bruncakova K.;Polakovicova L.;Sobona V.;Novak-Supe B.;Pekle-Golez A.;Jovanov M.;Strazisar B.;Markovic-Bozic J.;Novak-Jankovic V.;Voje M.;Grynyuk A.;Kostadinov I.;Spindler-Vesel A.;Moral V.;Unzueta M. C.;Puigbo C.;Fava J.;Canet J.;Moret E.;Rodriguez Nunez M.;Sendra M.;Brunelli A.;Rodenas F.;Monedero P.;Martinez F. H.;Temino M. J. Y.;Martinez Simon A.;de Abajo Larriba A.;Lisi A.;Perez G.;Martinez R.;Granell M.;Vivo J. T.;Ruiz C. S.;de Andres Ibanez J. A.;Pastor E.;Soro M.;Ferrando C.;Defez M.;Alvares-Santullano C. A.;Perez R.;Rico J.;Jawad M.;Saeed Y.;Gillberg L.;Bengisun Z. K.;Kazbek B. K.;Coskunfirat N.;Boztug N.;Sanli S.;Yilmaz M.;Hadimioglu N.;Senturk N. M.;Camci E.;Kucukgoncu S.;Sungur Z.;Sivrikoz N.;Ozgen S. U.;Toraman F.;Selvi O.;Senturk O.;Yildiz M.;Kuvaki B.;Gunenc F.;Kucukguclu S.;Ozbilgin S.;Maral J.;Canli S.;Arun O.;Saltali A.;Aydogan E.;Akgun F. N.;Sanlikarip C.;Karaman F. M.;Mazur A.;Vorotyntsev S.;Rousseau G.;Barrett C.;Stancombe L.;Shelley B.;Scholes H.;Limb J.;Rafi A.;Wayman L.;Deane J.;Rogerson D.;Williams J.;Yates S.;Rogers E.;Pulletz M.;Moreton S.;Jones S.;Venkatesh S.;Burton M.;Brown L.;Goodall C.;Rucklidge M.;Fuller D.;Nadolski M.;Kusre S.;Lundberg M.;Everett L.;Nutt H.;Zuleika M.;Carvalho P.;Clements D.;Creagh-Brown B.;Watt P.;Raymode P.;Pearse R.;Mohr O.;Raj A.;Creary T.;Chishti A.;Bell A.;Higham C.;Cain A.;Gibb S.;Mowat S.;Franklin D.;West C.;Minto G.;Boyd N.;Mills G.;Calton E.;Walker R.;Mackenzie F.;Ellison B.;Roberts H.;Chikungwa M.;Jackson C.;Donovan A.;Foot J.;Homan E.;Montgomery J.;Portch D.;Mercer P.;Palmer J.;Paddle J.;Fouracres A.;Datson A.;Andrew A.;Welch L.;Rose A.;Varma S.;Simeson K.;Rambhatla M.;Susarla J.;Marri S.;Kodaganallur K.;Das A.;Algarsamy S.;Colley J.;Davies S.;Szewczyk M.;Smith T.;Fernandez-Bustamante A.;Luzier E.;Almagro A.;Melo M. V.;Fernando L.;Sulemanji D.;Sprung J.;Weingarten T.;Kor D.;Scavonetto F.;Tze Y.

2021-01-01

Abstract

Background: It is uncertain whether the association of the intraoperative driving pressure (ΔP) with postoperative pulmonary complications (PPCs) depends on the surgical approach during abdominal surgery. Our primary objective was to determine and compare the association of time–weighted average ΔP (ΔPTW) with PPCs. We also tested the association of ΔPTW with intraoperative adverse events. Methods: Posthoc retrospective propensity score–weighted cohort analysis of patients undergoing open or closed abdominal surgery in the ‘Local ASsessment of Ventilatory management during General Anaesthesia for Surgery’ (LAS VEGAS) study, that included patients in 146 hospitals across 29 countries. The primary endpoint was a composite of PPCs. The secondary endpoint was a composite of intraoperative adverse events. Results: The analysis included 1128 and 906 patients undergoing open or closed abdominal surgery, respectively. The PPC rate was 5%. ΔP was lower in open abdominal surgery patients, but ΔPTW was not different between groups. The association of ΔPTW with PPCs was significant in both groups and had a higher risk ratio in closed compared to open abdominal surgery patients (1.11 [95%CI 1.10 to 1.20], P < 0.001 versus 1.05 [95%CI 1.05 to 1.05], P < 0.001; risk difference 0.05 [95%CI 0.04 to 0.06], P < 0.001). The association of ΔPTW with intraoperative adverse events was also significant in both groups but had higher odds ratio in closed compared to open abdominal surgery patients (1.13 [95%CI 1.12– to 1.14], P < 0.001 versus 1.07 [95%CI 1.05 to 1.10], P < 0.001; risk difference 0.05 [95%CI 0.030.07], P < 0.001). Conclusions: ΔP is associated with PPC and intraoperative adverse events in abdominal surgery, both in open and closed abdominal surgery. Trial registration: LAS VEGAS was registered at clinicaltrials.gov (trial identifier NCT01601223).

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	Anno
	
				2021
			
	Anno di pubblicazione online
	
				2021
			
	Rivista
	
				BMC ANESTHESIOLOGY
			
	DOI
	
				https://dx.doi.org/10.1186/s12871-021-01268-y
			
	Codice PUBMED
	
				33740885
			
	Codice Web of Science
	
				WOS:000631503200002
			
	Codice Scopus
	
				2-s2.0-85102932125
			
	Parole chiave
	
				Driving pressure; Laparoscopic surgery; Laparoscopy; PEEP; Perioperative ventilation; Pneumoperitoneum; Protective ventilation; Respiratory mechanics
			
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						Mazzinari, G.; Serpa Neto, A.; Hemmes, S. N. T.; Hedenstierna, G.; Jaber, S.; Hiesmayr, M.; Hollmann, M. W.; Mills, G. H.; Vidal Melo, M. F.; Pearse, ...espandi
						
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The Association of Intraoperative driving pressure with postoperative pulmonary complications in open versus closed abdominal surgery patients – a posthoc propensity score–weighted cohort analysis of the LAS VEGAS study

2021-01-01

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