SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.

Characterization of a Lineage C.36 SARS-CoV-2 Isolate with Reduced Susceptibility to Neutralization Circulating in Lombardy, Italy

Baj, Andreina
Co-primo
;
Novazzi, Federica;Dalla Gasperina, Daniela;Maggi, Fabrizio
Penultimo
;
2021-01-01

Abstract

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
Castelli, Matteo; Baj, Andreina; Criscuolo, Elena; Ferrarese, Roberto; Diotti, Roberta A.; Sampaolo, Michela; Novazzi, Federica; Dalla Gasperina, Daniela; Focosi, Daniele; Ferrari, Davide; Locatelli, Massimo; Clementi, Massimo; Clementi, Nicola; Maggi, Fabrizio; Mancini, Nicasio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2114744
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