SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.

Characterization of a lineage C.36 SARS-CoV-2 isolate with reduced susceptibility to neutralization circulating in Lombardy, Italy

Baj, Andreina
Co-primo
;
Novazzi, Federica;Dalla Gasperina, Daniela;Maggi, Fabrizio
Penultimo
;
Mancini, Nicasio
Ultimo
2021-01-01

Abstract

SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
2021
SARS-CoV-2; COVID-19; variant of concern; L452R; R346K; spike
Castelli, Matteo; Baj, Andreina; Criscuolo, Elena; Ferrarese, Roberto; Diotti, Roberta A.; Sampaolo, Michela; Novazzi, Federica; Dalla Gasperina, Dani...espandi
File in questo prodotto:
File Dimensione Formato  
viruses-13-01514.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 1.49 MB
Formato Adobe PDF
1.49 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2114744
 Attenzione

L'Ateneo sottopone a validazione solo i file PDF allegati

Citazioni
  • ???jsp.display-item.citation.pmc??? 9
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 9
social impact