Concerns exist about the efficacy of COVID-19 vaccines against immune escape by viral variants of concern (VOCs): Delta is currently the most common VOC worldwide (1), and nasopharyngeal swabs (NPSs) show that fully vaccinated persons, like unvaccinated persons, harbor infectious viral loads (2). Reports to date have assessed the prevalence of vaccine breakthrough (VBT) infection among health care workers (HCWs), mostly based on spontaneous self-reporting by symptomatic HCWs and hence missing asymptomatic persons, who could nevertheless transmit the pathogen. Once a positive result is identified in an HCW, most countries ask for a 14-day quarantine or 2 consecutive follow-ups after at least 10 days before the HCW is admitted back to the workplace. Such mandatory quarantines can lead to large HCW shortages and cause health crises in hospitals.

Asymptomatic SARS-CoV-2 vaccine breakthrough infections in health care workers identified through routine universal surveillance testing

Novazzi, Federica;Baj, Andreina;Maggi, Fabrizio
2021

Abstract

Concerns exist about the efficacy of COVID-19 vaccines against immune escape by viral variants of concern (VOCs): Delta is currently the most common VOC worldwide (1), and nasopharyngeal swabs (NPSs) show that fully vaccinated persons, like unvaccinated persons, harbor infectious viral loads (2). Reports to date have assessed the prevalence of vaccine breakthrough (VBT) infection among health care workers (HCWs), mostly based on spontaneous self-reporting by symptomatic HCWs and hence missing asymptomatic persons, who could nevertheless transmit the pathogen. Once a positive result is identified in an HCW, most countries ask for a 14-day quarantine or 2 consecutive follow-ups after at least 10 days before the HCW is admitted back to the workplace. Such mandatory quarantines can lead to large HCW shortages and cause health crises in hospitals.
File in questo prodotto:
File Dimensione Formato  
aim-olf-M213486.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: DRM non definito
Dimensione 95.47 kB
Formato Adobe PDF
95.47 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/2117824
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus ND
  • ???jsp.display-item.citation.isi??? 0
social impact