In order to identify biomarkers able to predict lung cancer risk in women surviving breast cancer, the hormone status and the expression of markers involved in DNA repair, DNA synthesis, and cell division were investigated. Breast cancer patients reporting alteration of DNA-repair machinery (BRCA1/2) and reduction of microtubule dynamicity (TUBB3) seem more susceptible to developing lung cancer after therapy-related DNA-damaging effects.

Radiation-Related Deregulation of TUBB3 and BRCA1/2 and Risk of Secondary Lung Cancer in Women With Breast Cancer

Grossi F.
2020-01-01

Abstract

In order to identify biomarkers able to predict lung cancer risk in women surviving breast cancer, the hormone status and the expression of markers involved in DNA repair, DNA synthesis, and cell division were investigated. Breast cancer patients reporting alteration of DNA-repair machinery (BRCA1/2) and reduction of microtubule dynamicity (TUBB3) seem more susceptible to developing lung cancer after therapy-related DNA-damaging effects.
2020
BRCA1/2 compensatory effect; DNA-repair pathway; Hormonal asset; Lung cancer risk; Secondary unrelated cancer
Coco, S.; Boccardo, S.; Mora, M.; Fontana, V.; Vanni, I.; Genova, C.; Alama, A.; Salvi, S.; Dal Bello, M. G.; Bonfiglio, S.; Rijavec, E.; Sini, C.; Barletta, G.; Biello, F.; Carli, F.; Cavalieri, Z.; Burrafato, G.; Longo, L.; Ballestrero, A.; Grossi, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2118664
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