Objective: Islet after kidney transplantation has been shown to positively affect the quality of life for individuals with type 1 diabetes (T1D) by reducing the burden of diabetic complications, but fewer data are available for Islet transplantation alone (ITA). The aim of this study was to assess whether ITA has a positive impact on hemostatic and cerebral abnormalities in individuals with T1D.Research Design and Methods: Pro-thrombotic factors, platelet function/ultrastructure, cerebral morphology, metabolism and function have been investigated over a 15-month follow-up period, with ELISA/electron microscopy and magnetic resonance imaging, nuclear magnetic resonance spectroscopy (1H-MRS) and neuropsychological evaluation (POMS and PASAT tests), in 22 individuals with T1D who underwent islet transplantation alone (n=12) or remained on the waiting list (n=10). Patients were homogeneous at the time of enrolment on the waiting list with regard to metabolic criteria, hemostatic parameters and cerebral morphology/metabolism/function. Results: At 15 months follow-up, the Islet transplantation alone group, but not individuals with T1D remaining on the waiting list, showed: i) improved glucose metabolism; ii) near-normal platelet activation and pro-thrombotic factor levels; iii) near-normal cerebral metabolism and function; and iv) a near-normal neuropsychological test. Conclusion: Islet transplantation alone, despite immunosuppressive therapy, is associated with a near- normalization of hemostatic and cerebral abnormalities

Islet transplantation stabilizes hemostatic abnormalities and cerebral metabolism in individuals with type 1 diabetes

La Rosa S;
2014-01-01

Abstract

Objective: Islet after kidney transplantation has been shown to positively affect the quality of life for individuals with type 1 diabetes (T1D) by reducing the burden of diabetic complications, but fewer data are available for Islet transplantation alone (ITA). The aim of this study was to assess whether ITA has a positive impact on hemostatic and cerebral abnormalities in individuals with T1D.Research Design and Methods: Pro-thrombotic factors, platelet function/ultrastructure, cerebral morphology, metabolism and function have been investigated over a 15-month follow-up period, with ELISA/electron microscopy and magnetic resonance imaging, nuclear magnetic resonance spectroscopy (1H-MRS) and neuropsychological evaluation (POMS and PASAT tests), in 22 individuals with T1D who underwent islet transplantation alone (n=12) or remained on the waiting list (n=10). Patients were homogeneous at the time of enrolment on the waiting list with regard to metabolic criteria, hemostatic parameters and cerebral morphology/metabolism/function. Results: At 15 months follow-up, the Islet transplantation alone group, but not individuals with T1D remaining on the waiting list, showed: i) improved glucose metabolism; ii) near-normal platelet activation and pro-thrombotic factor levels; iii) near-normal cerebral metabolism and function; and iv) a near-normal neuropsychological test. Conclusion: Islet transplantation alone, despite immunosuppressive therapy, is associated with a near- normalization of hemostatic and cerebral abnormalities
2014
D'Addio, F; Maffi, P; Vezzulli, P; Vergani, A; Mello, A; Bassi, R; Nano, R; Falautano, M; Coppi, E; Finzi, G; D'Angelo, A; Fermo, I; Pellegatta, F; La Rosa, S; Magnani, G; Piemonti, L; Falini, A; Folli, F; Secchi, A; Fiorina, P
File in questo prodotto:
File Dimensione Formato  
Diabetes Care 2014.pdf

non disponibili

Tipologia: Versione Editoriale (PDF)
Licenza: DRM non definito
Dimensione 1.37 MB
Formato Adobe PDF
1.37 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2119879
Citazioni
  • ???jsp.display-item.citation.pmc??? 16
  • Scopus 39
  • ???jsp.display-item.citation.isi??? 33
social impact