We describe a challenging case of a patient with MBL-producing Pseudomonas aeruginosa sternal osteomyelitis following aortic valve replacement with biological prosthesis. The strain exhibited a multidrug-resistance phenotype carrying the blaVIM-1 gene and belonged to the high-risk clone sequence type ST235. The patient was successfully treated with surgical debridement plus antibiotic therapy with ceftazidime/avibactam, aztreonam, and amikacin. Time kill curves showed that this triple antibiotic combination at 1 X MIC was strongly synergic after 8 hours, achieving 99.9% killing, and maintaining this until 48 hours.

Combination of aztreonam, ceftazidime-avibactam and amikacin in the treatment of VIM-1 Pseudomonas aeruginosa ST235 osteomyelitis

Grossi, Paolo
Ultimo
Membro del Collaboration Group
2021-01-01

Abstract

We describe a challenging case of a patient with MBL-producing Pseudomonas aeruginosa sternal osteomyelitis following aortic valve replacement with biological prosthesis. The strain exhibited a multidrug-resistance phenotype carrying the blaVIM-1 gene and belonged to the high-risk clone sequence type ST235. The patient was successfully treated with surgical debridement plus antibiotic therapy with ceftazidime/avibactam, aztreonam, and amikacin. Time kill curves showed that this triple antibiotic combination at 1 X MIC was strongly synergic after 8 hours, achieving 99.9% killing, and maintaining this until 48 hours.
2021
2021
Pseudomonas aeruginosa; ST235; VIM-1; aztreonam; ceftazidime-avibactam; osteomyelitis
Mularoni, Alessandra; Mezzatesta, Maria Lina; Pilato, Michele; Medaglia, Alice Annalisa; Cervo, Adriana; Bongiorno, Dafne; Aprile, Ausilia; Luca, Angelo; Stefani, Stefania; Grossi, Paolo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2123334
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