The Delta variant of concern (VOC) of SARS-CoV-2 has become dominant worldwide. We report here a cluster caused by B.1.617.2 harboring the additional mutation of concern (MOC) F490S. Infection occurred in 5 fully vaccinated subjects between the ages of 47 and 84. The immune escape mutation F490S, first identified in the Lambda VOI, appears to impair vaccine efficacy and is rapidly increasing in prevalence worldwide.

A CLUSTER OF SARS-COV-2 DELTA VARIANT OF CONCERN ADDITIONALLY HARBORING F490S, NORTHERN LOMBARDY, ITALY

Novazzi, Federica
Primo
;
Baj, Andreina
Secondo
;
Genoni, Angelo;Maggi, Fabrizio
Ultimo
2022-01-01

Abstract

The Delta variant of concern (VOC) of SARS-CoV-2 has become dominant worldwide. We report here a cluster caused by B.1.617.2 harboring the additional mutation of concern (MOC) F490S. Infection occurred in 5 fully vaccinated subjects between the ages of 47 and 84. The immune escape mutation F490S, first identified in the Lambda VOI, appears to impair vaccine efficacy and is rapidly increasing in prevalence worldwide.
2022
2022
B.1.617.2; COVID-19; Delta; F490S; SARS-CoV-2; variant of concern.
Novazzi, Federica; Baj, Andreina; Pasciuta, Renee; Genoni, Angelo; Ferrante, Francesca Drago; Tripiciano, Rosalia; Catanoso, Giuseppe; Focosi, Daniele; Maggi, Fabrizio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2125566
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