Aim: To assess real-world ruxolitinib treatment patterns and outcomes in patients diagnosed with primary or secondary myelofibrosis. Materials & methods: Patient medical records were reviewed in six countries. Results: Eligible patients (n = 469) had a mean age of 63.5 years, and most were male (66.5%) with primary myelofibrosis (78.5%). Median duration of ruxolitinib treatment was 13.1 months; 40% of patients initiated treatment at the recommended dose. The Kaplan-Meier estimate of median survival from ruxolitinib initiation was 44.4 months (95% CI, 38.8-50.2 months). Approximately one quarter (23%) of patients continued ruxolitinib after progression. Conclusion: These results suggest an unmet need for more effective treatments for patients with myelofibrosis who failed ruxolitinib.

Real-world clinical outcomes of patients with myelofibrosis treated with ruxolitinib: a medical record review

Passamonti F.
Primo
;
2022-01-01

Abstract

Aim: To assess real-world ruxolitinib treatment patterns and outcomes in patients diagnosed with primary or secondary myelofibrosis. Materials & methods: Patient medical records were reviewed in six countries. Results: Eligible patients (n = 469) had a mean age of 63.5 years, and most were male (66.5%) with primary myelofibrosis (78.5%). Median duration of ruxolitinib treatment was 13.1 months; 40% of patients initiated treatment at the recommended dose. The Kaplan-Meier estimate of median survival from ruxolitinib initiation was 44.4 months (95% CI, 38.8-50.2 months). Approximately one quarter (23%) of patients continued ruxolitinib after progression. Conclusion: These results suggest an unmet need for more effective treatments for patients with myelofibrosis who failed ruxolitinib.
2022
2022
medical record review; myelofibrosis; real-world data; ruxolitinib; survival analysis; Female; Humans; Male; Medical Records; Middle Aged; Nitriles; Pyrazoles; Pyrimidines; Treatment Outcome; Primary Myelofibrosis
Passamonti, F.; Heidel, F. H.; Parikh, R. C.; Ajmera, M.; Tang, D.; Nadal, J. A.; Davis, K. L.; Abraham, P.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2137170
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