Cell therapy with autologous peripheral blood mononuclear cells (PB-MNCs) may help restore limb perfusion in patients with diabetes mellitus and critical limb-threatening ischemia (CLTI) deemed not eligible for revascularization procedures and consequently at risk for major amputation (no-option). Fundamental is to establish its clinical value and to identify candidates with a greater benefit over time. Assessing the frequency of PB circulating angiogenic cells and extracellular vesicles (EVs) may help in guiding candidate selection.

Results of a prospective observational study of autologous peripheral blood mononuclear cell therapy for no-option critical limb-threatening ischemia and severe diabetic foot ulcers

Bruno, Antonino;
2022

Abstract

Cell therapy with autologous peripheral blood mononuclear cells (PB-MNCs) may help restore limb perfusion in patients with diabetes mellitus and critical limb-threatening ischemia (CLTI) deemed not eligible for revascularization procedures and consequently at risk for major amputation (no-option). Fundamental is to establish its clinical value and to identify candidates with a greater benefit over time. Assessing the frequency of PB circulating angiogenic cells and extracellular vesicles (EVs) may help in guiding candidate selection.
Autologous cell therapy; Critical limb-threatening ischemia; Diabetes mellitus; Amputation; Humans; Ischemia; Leukocytes, Mononuclear; Limb Salvage; Oxygen; Prospective Studies; Treatment Outcome; Diabetes Mellitus; Diabetic Foot
Panunzi, Andrea; Madotto, Fabiana; Sangalli, Elena; Riccio, Federica; Sganzaroli, Adriana Barbara; Galenda, Paolo; Bertulessi, Amelia; Barmina, Maria Francesca; Ludovico, Ornella; Fortunato, Orazio; Setacci, Francesco; Airoldi, Flavio; Tavano, Davide; Giurato, Laura; Meloni, Marco; Uccioli, Luigi; Bruno, Antonino; Spinetti, Gaia; Caravaggi, Carlo Maria Ferdinando
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2140831
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