We present three cases of pre-term low-weight infants with suspected necrotizing enterocolitis (NEC) [one eventually recognized as a connatal cytomegalovirus (CMV) infection], microbiologically monitored using a molecular assay detecting bacterial and fungal DNA in blood. The detection of DNA from enteric pathogens in blood was interpreted as a sign of ongoing perforation, and represented a useful complement in the management of the presented cases. Moreover, these cases suggest the opportunity for larger future studies to assess the possible role of a molecular approach in the close monitoring of infants with suspected NEC or with other conditions at-risk for intestinal perforation.

Potential role of the detection of enterobacterial DNA in blood for the management of neonatal necrotizing enterocolitis

MANCINI , NICASIO;
2012-01-01

Abstract

We present three cases of pre-term low-weight infants with suspected necrotizing enterocolitis (NEC) [one eventually recognized as a connatal cytomegalovirus (CMV) infection], microbiologically monitored using a molecular assay detecting bacterial and fungal DNA in blood. The detection of DNA from enteric pathogens in blood was interpreted as a sign of ongoing perforation, and represented a useful complement in the management of the presented cases. Moreover, these cases suggest the opportunity for larger future studies to assess the possible role of a molecular approach in the close monitoring of infants with suspected NEC or with other conditions at-risk for intestinal perforation.
2012
2012
Mancini, Nicasio; Poloniato, A; Ghidoli, N; Carletti, S; Fomasi, M; Barera, G; Rovelli, R; Cichero, P; Burioni, Roberto; Clementi, Massimo
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2149027
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