Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review describes the potential of several T-cell-based therapeutic approaches in the prophylaxis and treatment of infectious diseases with a particular focus on persistent viral infections and opportunistic fungal infections, as these mostly affect immunocompromised patients.

Adoptive T-cell therapy in the treatment of viral and opportunistic fungal infections

MANCINI, NICASIO
;
CLEMENTI, MASSIMO;
2015-01-01

Abstract

Viral infections and opportunistic fungal pathogens represent a major menace for immunocompromised patients. Despite the availability of antifungal and antiviral drugs, mortality in these patients remains high, underlining the need of novel therapeutic options based on completely different strategies. This review describes the potential of several T-cell-based therapeutic approaches in the prophylaxis and treatment of infectious diseases with a particular focus on persistent viral infections and opportunistic fungal infections, as these mostly affect immunocompromised patients.
2015
2015
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84927749704&doi=10.2217/fmb.14.122&partnerID=40&md5=8e2601eba78889a7d5e9ee0eb3003389
T cell; T-cell receptor; adoptive T-cell therapy; chimeric antigen receptor; fungal infections; immunocompromised patients; infectious diseases; viral infections
Mancini, Nicasio; Marrone, L; Clementi, Nicola; Sautto, Ga; Clementi, Massimo; Burioni, Roberto
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2149029
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