The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this “novel” evasion strategy.

Neutralization Interfering Antibodies: a "Novel" Mechanism of Humoral Immune Mutiny and Viral Evasion?

MANCINI, NICASIO
;
CLEMENTI, MASSIMO;
2012-01-01

Abstract

The immune response against some viral pathogens, in particular those causing chronic infections, is often ineffective notwithstanding a robust humoral neutralizing response. Several evasion mechanisms capable of subverting the activity of neutralizing antibodies (nAbs) have been described. Among them, the elicitation of non-neutralizing and interfering Abs has been hypothesized. Recently, this evasion mechanism has acquired an increasing interest given its possible impact on novel nAb-based antiviral therapeutic and prophylactic approaches. In this review, we illustrate the mechanisms of Ab-mediated interference and the viral pathogens described in literature as able to adopt this “novel” evasion strategy.
2012
2012
https://www.mdpi.com/1999-4915/4/9/1731
neutralizing antibodies; non-neutralizing antibodies; interfering antibodies; viral escape mechanism
Mancini, Nicasio; Sautto, G; Clementi, Nicola; Diotti, Ra; Castelli, M; Criscuolo, E; Solforosi, L; Clementi, Massimo; Burioni, Roberto; Castelli, Matteo; Criscuolo, Elena
File in questo prodotto:
File Dimensione Formato  
2012Viruses-hcv.pdf

accesso aperto

Tipologia: Versione Editoriale (PDF)
Licenza: Creative commons
Dimensione 825.1 kB
Formato Adobe PDF
825.1 kB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2149072
Citazioni
  • ???jsp.display-item.citation.pmc??? 17
  • Scopus 24
  • ???jsp.display-item.citation.isi??? 23
social impact