Pretreatment with intracerebroventricular pertussis toxin six days before, abolished analgesia induced by central morphine in the hot plate test. In contrast the toxin did not affect analgesia evoked by neurotensin and ASU 1-7 Eel calcitonin. The role of G proteins in opioid and non-opioid analgesia is discussed.
Effect of pertussis toxin on opioid and non-opioid induced analgesia
Parolaro D.;Rubino T.;
1990-01-01
Abstract
Pretreatment with intracerebroventricular pertussis toxin six days before, abolished analgesia induced by central morphine in the hot plate test. In contrast the toxin did not affect analgesia evoked by neurotensin and ASU 1-7 Eel calcitonin. The role of G proteins in opioid and non-opioid analgesia is discussed.
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