Novel copper(II) coordination polymers (CPs) [Cu(μ-4-NO2pz)2]n and [Cu(μ-4-NO2pz)2·DMF H2O]n (4-NO2pz− = 4-nitropyrazolate; DMF = N,N′-dimethylformamide) were synthesized and characterized in the solid state and their thermal behaviour and structural features were investigated. Together with the known CPs [Cu(μ-pz)(μ-OH)]n, [Cu(μ-pz)2(H2O)]n and [Cu(μ-4-Xpz)2(DMF)]n [pz− = pyrazolate; 4-Xpz− = 4-X-pyrazolate, with X = H, Cl, Br, I], they were isolated in the form of very small particles whose dimensions range within 20-300 nm and, as such, they were investigated as potential antibacterial agents. Their antibacterial activity was assessed against two Gram-negative bacteria, namely Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), and the Gram-positive bacterium Staphylococcus aureus (S. aureus), by monitoring the bacterial growth curve and the antibacterial rate as a function of time. The bactericidal mechanism seems to be related to the ROS production, directly activated by the contact of the CP tiny particles with the bacterial membrane, without a significant release of Cu(II) ions.

Antibacterial activity of copper pyrazolate coordination polymers

Moroni M.;Galli S.;
2023-01-01

Abstract

Novel copper(II) coordination polymers (CPs) [Cu(μ-4-NO2pz)2]n and [Cu(μ-4-NO2pz)2·DMF H2O]n (4-NO2pz− = 4-nitropyrazolate; DMF = N,N′-dimethylformamide) were synthesized and characterized in the solid state and their thermal behaviour and structural features were investigated. Together with the known CPs [Cu(μ-pz)(μ-OH)]n, [Cu(μ-pz)2(H2O)]n and [Cu(μ-4-Xpz)2(DMF)]n [pz− = pyrazolate; 4-Xpz− = 4-X-pyrazolate, with X = H, Cl, Br, I], they were isolated in the form of very small particles whose dimensions range within 20-300 nm and, as such, they were investigated as potential antibacterial agents. Their antibacterial activity was assessed against two Gram-negative bacteria, namely Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), and the Gram-positive bacterium Staphylococcus aureus (S. aureus), by monitoring the bacterial growth curve and the antibacterial rate as a function of time. The bactericidal mechanism seems to be related to the ROS production, directly activated by the contact of the CP tiny particles with the bacterial membrane, without a significant release of Cu(II) ions.
2023
2023
Di Nicola, C.; Marchetti, F.; Tombesi, A.; Xhafa, S.; Campitelli, P.; Moroni, M.; Galli, S.; Pettinari, R.; Pettinari, C.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2163891
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