Novel copper(II) coordination polymers (CPs) [Cu(μ-4-NO2pz)2]n and [Cu(μ-4-NO2pz)2·DMF H2O]n (4-NO2pz− = 4-nitropyrazolate; DMF = N,N′-dimethylformamide) were synthesized and characterized in the solid state and their thermal behaviour and structural features were investigated. Together with the known CPs [Cu(μ-pz)(μ-OH)]n, [Cu(μ-pz)2(H2O)]n and [Cu(μ-4-Xpz)2(DMF)]n [pz− = pyrazolate; 4-Xpz− = 4-X-pyrazolate, with X = H, Cl, Br, I], they were isolated in the form of very small particles whose dimensions range within 20-300 nm and, as such, they were investigated as potential antibacterial agents. Their antibacterial activity was assessed against two Gram-negative bacteria, namely Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), and the Gram-positive bacterium Staphylococcus aureus (S. aureus), by monitoring the bacterial growth curve and the antibacterial rate as a function of time. The bactericidal mechanism seems to be related to the ROS production, directly activated by the contact of the CP tiny particles with the bacterial membrane, without a significant release of Cu(II) ions.
Antibacterial activity of copper pyrazolate coordination polymers
Moroni M.;Galli S.;
2023-01-01
Abstract
Novel copper(II) coordination polymers (CPs) [Cu(μ-4-NO2pz)2]n and [Cu(μ-4-NO2pz)2·DMF H2O]n (4-NO2pz− = 4-nitropyrazolate; DMF = N,N′-dimethylformamide) were synthesized and characterized in the solid state and their thermal behaviour and structural features were investigated. Together with the known CPs [Cu(μ-pz)(μ-OH)]n, [Cu(μ-pz)2(H2O)]n and [Cu(μ-4-Xpz)2(DMF)]n [pz− = pyrazolate; 4-Xpz− = 4-X-pyrazolate, with X = H, Cl, Br, I], they were isolated in the form of very small particles whose dimensions range within 20-300 nm and, as such, they were investigated as potential antibacterial agents. Their antibacterial activity was assessed against two Gram-negative bacteria, namely Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), and the Gram-positive bacterium Staphylococcus aureus (S. aureus), by monitoring the bacterial growth curve and the antibacterial rate as a function of time. The bactericidal mechanism seems to be related to the ROS production, directly activated by the contact of the CP tiny particles with the bacterial membrane, without a significant release of Cu(II) ions.File | Dimensione | Formato | |
---|---|---|---|
137_New_J_Chem_2023_47_19047.pdf
accesso aperto
Tipologia:
Versione Editoriale (PDF)
Licenza:
Creative commons
Dimensione
2.31 MB
Formato
Adobe PDF
|
2.31 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.