INTRODUCTION: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. AIM: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. METHODS: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. MAIN OUTCOME MEASURES: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. RESULTS: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ(2) = 24.7; P < 0.01). Both patient age and AD comorbidity achieved multivariable independent predictor status for PD (odds ratio [OR]: 1.05; P < 0.01 and OR: 4.90; P < 0.01, respectively). CONCLUSIONS: Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting.

Peyronie's disease and autoimmunity—a real-life clinical study and comprehensive review

Capogrosso P;
2015-01-01

Abstract

INTRODUCTION: Although heavily investigated over the last decades, Peyronie's disease (PD) pathogenesis remains unclear. AIM: We sought to investigate the association between PD and autoimmune diseases (ADs) in men seeking medical help for sexual dysfunction in the real-life setting. METHODS: Complete sociodemographic and clinical data from a homogenous cohort of 1,140 consecutive Caucasian-European men were analyzed. Health-significant comorbidities were scored with the Charlson Comorbidity Index and ADs were stratified according to International Classification of Diseases, Ninth Revision classification. MAIN OUTCOME MEASURES: Descriptive statistics and multivariate logistic regression models tested the association between ADs and PD. RESULTS: PD was diagnosed in 148 (13%) of the 1,140 men; of PD patients, 14 (9.5%) had a comorbid AD; conversely, the rate of ADs in non-PD patients was significantly lower (χ(2) = 24.7; P < 0.01). Both patient age and AD comorbidity achieved multivariable independent predictor status for PD (odds ratio [OR]: 1.05; P < 0.01 and OR: 4.90; P < 0.01, respectively). CONCLUSIONS: Our observational findings showed that ADs are highly comorbid with PD in a large cohort of same-race individuals seeking medical help for sexual dysfunction in the real-life setting.
2015
2015
Autoimmune Disease; Peyronie's Disease; Psoriasis; Sexual Dysfunction.
Ventimiglia, Eugenio; Capogrosso, P; Colicchia, Michele; Boeri, Luca; Serino, Alessandro; La Croce, Giovanni; Russo, Andrea; Capitanio, Umberto; Briganti, Alberto; Cantiello, Francesco; Mirone, Vincenzo; Damiano, Rocco; Montorsi, Francesco; Salonia, Andrea
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2167719
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