The majority of fatal cases of SARS-CoV-2 was concentrated among older patients. We aimed at assessing risk factors contributing to mortality in this population. A retrospective study including 584 COVID-19 patients aged >= 80 years hospitalized between October 10th 2020 to May 4th 2021 at Ospedale di Circolo (Varese, Italy) and Ospedale Galmarini (Tradate, Italy) was conducted. Evaluation of risk factors associated with in-hospital mortality was the primary endpoint. 509 patients were considered. Median age was 86 [82-89] years. Almost half of the patients (n=241) suffered from >= 3 comorbidities. Overall in-hospital mortality was 39.7% (n=202). Age, chronic kidney disease (CKD), peripheral oxygen saturation at admission, and high-flow oxygen during hospital stay independently predicted in-hospital mortality. Overall mortality at 6 months was 57.8% (n=294) and increased with increasing age and number of comorbidities (P<0.05). Age, CKD, and dementia independently predicted 6-month mortality. Age and comorbidities predicted short- and long-term mortality in older patients (>= 80 years). Stratification of patients according to age and comorbidities might provide critical information for a better management of elderly patients.

Clinical factors affecting short- and long-term mortality in older patients with COVID-19: a retrospective cohort study

Pennella B.
;
Rotunno F.;Guerci M.;Biancucci M.;Troian F.;Tripodi P. M.;Gilio A.;Gasperina D. D.;Dentali F.;Maresca A. M.
Ultimo
2024-01-01

Abstract

The majority of fatal cases of SARS-CoV-2 was concentrated among older patients. We aimed at assessing risk factors contributing to mortality in this population. A retrospective study including 584 COVID-19 patients aged >= 80 years hospitalized between October 10th 2020 to May 4th 2021 at Ospedale di Circolo (Varese, Italy) and Ospedale Galmarini (Tradate, Italy) was conducted. Evaluation of risk factors associated with in-hospital mortality was the primary endpoint. 509 patients were considered. Median age was 86 [82-89] years. Almost half of the patients (n=241) suffered from >= 3 comorbidities. Overall in-hospital mortality was 39.7% (n=202). Age, chronic kidney disease (CKD), peripheral oxygen saturation at admission, and high-flow oxygen during hospital stay independently predicted in-hospital mortality. Overall mortality at 6 months was 57.8% (n=294) and increased with increasing age and number of comorbidities (P<0.05). Age, CKD, and dementia independently predicted 6-month mortality. Age and comorbidities predicted short- and long-term mortality in older patients (>= 80 years). Stratification of patients according to age and comorbidities might provide critical information for a better management of elderly patients.
2024
2024
COVID-19; SARS-CoV-2; older patients; mortality; frailty
Pennella, B.; Rotunno, F.; Mercuri, M.; Guerci, M.; Molteni, M.; Biancucci, M.; Berton, C.; Troian, F.; Tripodi, P. M.; Gilio, A.; Milano, A.; Gasperina, D. D.; Dentali, F.; Bonaventura, A.; Maresca, A. M.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2172532
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