Atomic-level control over the position and growth of a s ingle and continuous metal chain is an ambitious goal that often requires complex and costly processes. H erein, we demonstrate that 1Pd-DNA molecules, comprising a continuous single chain of Pd(II) ions, c an be prepared by a s imple self-assembly reaction between the complex [Pd(Cheld)(CH3CN)] (1Pd_CH3CN) (Cheld = chelidamic acid) and single-stranded DNA homopolymers (ss-DNA) containing adenine (A) or 7- deazaadenine (X) bases. The single Pd(II)-base pairs [1Pd(N1-A)] and [1Pd(N1-X)] were synthesized and characterized in solution and solid-state (X-ray diffraction) revealing an arrangement similar to that of natural Watson–Crick base pairs. Subsequently, 1Pd-DNA hybrids were prepared, characterized, and their structures studied by small-angle X-ray scattering (SAXS) and ab-initio calculations. The results indicate that the 1Pd-DNA structures resemble that of double-stranded DNA, with one strand being replaced by a supramolecular stack of continuous Pd(II) complexes.

Single-Stranded DNA as Supramolecular Template for One-Dimensional Palladium(II) Arrays

Galli S.;
2021-01-01

Abstract

Atomic-level control over the position and growth of a s ingle and continuous metal chain is an ambitious goal that often requires complex and costly processes. H erein, we demonstrate that 1Pd-DNA molecules, comprising a continuous single chain of Pd(II) ions, c an be prepared by a s imple self-assembly reaction between the complex [Pd(Cheld)(CH3CN)] (1Pd_CH3CN) (Cheld = chelidamic acid) and single-stranded DNA homopolymers (ss-DNA) containing adenine (A) or 7- deazaadenine (X) bases. The single Pd(II)-base pairs [1Pd(N1-A)] and [1Pd(N1-X)] were synthesized and characterized in solution and solid-state (X-ray diffraction) revealing an arrangement similar to that of natural Watson–Crick base pairs. Subsequently, 1Pd-DNA hybrids were prepared, characterized, and their structures studied by small-angle X-ray scattering (SAXS) and ab-initio calculations. The results indicate that the 1Pd-DNA structures resemble that of double-stranded DNA, with one strand being replaced by a supramolecular stack of continuous Pd(II) complexes.
2021
2021
https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202015554
bioinorganic chemistry; DNA; metal-mediated base pair; palladium; self-assembly
Perez-Romero, A.; Dominguez-Martin, A.; Galli, S.; Santamaria-Diaz, N.; Palacios, O.; Dobado, J. A.; Nyman, M.; Galindo, M. A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2172572
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