Rheumatoid arthritis (RA) is a chronic systemic and arthritic autoimmune disease that affects millions of people worldwide. It is characterized by inflammation of the joints which can lead to the destruction of the periarticular tissue, causing thus chronic pain, joint deformities and consequently disability and deterioration of quality of life. During the last decades, scientific data has suggested that Proteus spp. have a key role in the aetiopathogenesis of RA. Current Guidelines on asymptomatic bacteriuria suggest to treat only patients that will benefit from treatment such as pregnant woman patients undergoing urologic procedures in which mucosal bleeding is expected and patients who are in the first month following renal transplantation. Given the involvement of Proteus on RA pathophysiology, treatment of asymptomatic bacteriuria from P. mirabilis may reduce the potential risk of RA development and progression. Here, we performed a review of the available literature regarding the association between RA and UTI caused by Proteus spp., and we discuss the abovementioned issue.
Treatment of asymptomatic bacteriuria from Proteus mirabilis may reduce the potential risk of rheumatoid arthritis development and progression
Gianpaolo Perletti;
2025-01-01
Abstract
Rheumatoid arthritis (RA) is a chronic systemic and arthritic autoimmune disease that affects millions of people worldwide. It is characterized by inflammation of the joints which can lead to the destruction of the periarticular tissue, causing thus chronic pain, joint deformities and consequently disability and deterioration of quality of life. During the last decades, scientific data has suggested that Proteus spp. have a key role in the aetiopathogenesis of RA. Current Guidelines on asymptomatic bacteriuria suggest to treat only patients that will benefit from treatment such as pregnant woman patients undergoing urologic procedures in which mucosal bleeding is expected and patients who are in the first month following renal transplantation. Given the involvement of Proteus on RA pathophysiology, treatment of asymptomatic bacteriuria from P. mirabilis may reduce the potential risk of RA development and progression. Here, we performed a review of the available literature regarding the association between RA and UTI caused by Proteus spp., and we discuss the abovementioned issue.
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