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Introduction: While smoking has been consistently identified as a significant contributor to postoperative complications, the existing literature on its association with postoperative pulmonary complications remains conflicting. Aim: We examined the association of preoperative smoking with the occurrence of postoperative pulmonary complications (PPCs). Methods: Post hoc analysis of an observational study in 146 hospitals across 29 countries. We included patients at increased risk of PPCs, according to the Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score (≥ 26 points). The primary endpoint was the occurrence of one or more predefined PPCs in the first five postoperative days, including unplanned postoperative need for supplementary oxygen, respiratory failure, unplanned need for invasive ventilation, ARDS, pneumonia and pneumothorax. Secondary endpoints included length of hospital stay and in–hospital mortality. We performed propensity score matching to correct for factors with a known association with postoperative outcomes. Results: Out of 2632 patients, 531 (20.2 %) patients were smokers and 2102 (79.8 %) non-smokers. At five days after surgery, 101 (19.0 %) smokers versus 404 (19.2) non–smokers had developed one or more PPCs (P = 0.95). Respiratory failure was more common in smokers (5.1 %) than non–smokers (3.0 %) (P = 0.02), while rates of other PPCs like need for supplementary oxygen, invasive ventilation, ARDS, pneumonia, or pneumothorax did not differ between the groups. Length of hospital stay and mortality was not different between groups. Propensity score matching did not change the findings. Conclusion: The occurrence of PPCs in smokers is not different from non–smokers. Funding: This analysis was performed without additional funding. LAS VEGAS was partially funded and endorsed by the European Society of Anaesthesiology through their Clinical Trial Network and the Amsterdam University Medical Centers, Amsterdam, The Netherlands. Registration: LAS VEGAS was registered at Clinicaltrials.gov (NCT01601223). Prior presentation: Preliminary study results have been presented at the Euroanaesthesia 2024 International Congress, in Munich, Germany.
Association of preoperative smoking with the occurrence of postoperative pulmonary complications: A post hoc analysis of an observational study in 29 countries
Dorland G.;Saadat W.;van Meenen D. M. P.;Neto A. S.;Hiesmayr M.;Hollmann M. W.;Mills G. H.;Vidal Melo M. F.;Putensen C.;Schmid W.;Severgnini P.;Wrigge H.;de Abreu M. G.;Schultz M. J.;Hemmes S. N. T.;Kroell W.;Metzler H.;Struber G.;Wegscheider T.;Gombotz H.;Hiesmayr M.;Schmid W.;Urbanek B.;Kahn D.;Momeni M.;Pospiech A.;Lois F.;Forget P.;Grosu I.;Poelaert J.;van Mossevelde V.;van Malderen M. -C.;Dylst D.;van Melkebeek J.;Beran M.;de Hert S.;De Baerdemaeker L.;Heyse B.;Van Limmen J.;Wyffels P.;Jacobs T.;Roels N.;De Bruyne A.;van de Velde S.;Leva B.;Damster S.;Plichon B.;Juros-Zovko M.;Djonovic-Omanovic D.;Pernar S.;Zunic J.;Miskovic P.;Zilic A.;Kvolik S.;Ivic D.;Azenic-Venzera D.;Skiljic S.;Vinkovic H.;Oputric I.;Juricic K.;Frkovic V.;Kopic J.;Mirkovic I.;Karanovic N.;Carev M.;Dropulic N.;Saric J. P.;Erceg G.;Dvorscak M. B.;Mazul-Sunko B.;Pavicic A. M.;Goranovic T.;Maldini B.;Radocaj T.;Gavranovic Z.;Mladic-Batinica I.;Sehovic M.;Stourac P.;Harazim H.;Smekalova O.;Kosinova M.;Kolacek T.;Hudacek K.;Drab M.;Brujevic J.;Vitkova K.;Jirmanova K.;Volfova I.;Dzurnakova P.;Liskova K.;Dudas R.;Filipsky R.;el Kafrawy S.;Abdelwahab H. H.;Metwally T.;Abdel-Razek A.;El-Shaarawy A. M.;Hasan W. F.;Ahmed A. G.;Yassin H.;Magdy M.;Abdelhady M.;Mahran M.;Herodes E.;Kivik P.;Oganjan J.;Aun A.;Sormus A.;Sarapuu K.;Mall M.;Karjagin J.;Futier E.;Petit A.;Gerard A.;Marret E.;Solier M.;Jaber S.;Prades A.;Krassler J.;Merzky S.;de Abreu M. G.;Uhlig C.;Kiss T.;Bundy A.;Bluth T.;Gueldner A.;Spieth P.;Scharffenberg M.;Thiem D. T.;Koch T.;Treschan T.;Schaefer M.;Bastin B.;Geib J.;Weiss M.;Kienbaum P.;Pannen B.;Gottschalk A.;Konrad M.;Westerheide D.;Schwerdtfeger B.;Wrigge H.;Simon P.;Reske A.;Nestler C.;Valsamidis D.;Stroumpoulis K.;Antholopoulos G.;Andreou A.;Karapanos D.;Theodoraki K.;Gkiokas G.;Tasoulis M. -K.;Sidiropoulou T.;Zafeiropoulou F.;Florou P.;Pandazi A.;Tsaousi G.;Nouris C.;Pourzitaki C.;Bystritski D.;Pizov R.;Eden A.;Pesce C. V.;Campanile A.;Marrella A.;Grasso S.;De Michele M.;Bona F.;Giacoletto G.;Sardo E.;Giancarlo L.;Sottosanti V.;Solca M.;Volta C. A.;Spadaro S.;Verri M.;Ragazzi R.;Zoppellari R.;Cinnella G.;Raimondo P.;La Bella D.;Mirabella L.;D'antini D.;Pelosi P.;Molin A.;Brunetti I.;Gratarola A.;Pellerano G.;Sileo R.;Pezzatto S.;Montagnani L.;Pasin L.;Landoni G.;Zangrillo A.;Beretta L.;Di Parma A. L.;Tarzia V.;Dossi R.;Sassone M. E.;Sances D.;Tredici S.;Spano G.;Castellani G.;Delunas L.;Peradze S.;Venturino M.;Arpino I.;Sher S.;Tommasino C.;Rapido F.;Morelli P.;Vargas M.;Servillo G.;Cortegiani A.;Raineri S. M.;Montalto F.;Russotto V.;Giarratano A.;Baciarello M.;Generali M.;Cerati G.;Leykin Y.;Bressan F.;Bartolini V.;Zamidei L.;Brazzi L.;Liperi C.;Sales G.;Pistidda L.;Severgnini P.;Brugnoni E.;Musella G.;Bacuzzi A.;Muhardri D.;Gecaj-Gashi A.;Sada F.;Bytyqi A.;Karbonskiene A.;Aukstakalniene R.;Teberaite Z.;Salciute E.;Tikuisis R.;Miliauskas P.;Jurate S.;Kontrimaviciute E.;Tomkute G.;Xuereb J.;Bezzina M.;Borg F. J.;Hemmes S.;Schultz M.;Hollmann M.;Wiersma I.;Binnekade J.;Bos L.;Boer C.;Duvekot A.;Veld B. I.;Werger A.;Dennesen P.;Severijns C.;De Jong J.;Hering J.;van Beek R.;Ivars S.;Jammer I.;Breidablik A.;Hodt K. S.;Fjellanger F.;Avalos M. V.;Mellin-Olsen J.;Andersson E.;Shafi-Kabiri A.;Molina R.;Wutai S.;Morais E.;Tareco G.;Ferreira D.;Amaral J.;de Lurdes Goncalves Castro M.;Cadilha S.;Appleton S.;Parente S.;Correia M.;Martins D.;Monteirosa A.;Ricardo A.;Rodrigues S.;Horhota L.;Grintescu I. M.;Mirea L.;Grintescu I. C.;Corneci D.;Negoita S.;Dutu M.;Garotescu I. P.;Filipescu D.;Prodan A. B.;Droc G.;Fota R.;Popescu M.;Tomescu D.;Petcu A. M.;Tudoroiu M. I.;Moise A.;Guran C. -T.;Gherghina I.;Costea D.;Cindea I.;Copotoiu S. -M.;Copotoiu R.;Barsan V.;Tolcser Z.;Riciu M.;Moldovan S. G.;Veres M.;Gritsan A.;Kapkan T.;Gritsan G.;Korolkov O.;Kulikov A.;Lubnin A.;Ovezov A.;Prokoshev P.;Lugovoy A.;Anipchenko N.;Babayants A.;Komissarova I.;Zalina K.;Likhvantsev V.;Fedorov S.;Lazukic A.;Pejakovic J.;Mihajlovic D.;Kusnierikova Z.;Zelinkova M.;Bruncakova K.;Polakovicova L.;Sobona V.;Novak-Supe B.;Pekle-Golez A.;Jovanov M.;Strazisar B.;Markovic-Bozic J.;Novak-Jankovic V.;Voje M.;Grynyuk A.;Kostadinov I.;Spindler-Vesel A.;Moral V.;Unzueta M. C.;Puigbo C.;Fava J.;Canet J.;Moret E.;Nunez M. R.;Sendra M.;Brunelli A.;Rodenas F.;Monedero P.;Martinez F. H.;Temino M. J. Y.;Simon A. M.;de Abajo Larriba A.;Lisi A.;Perez G.;Martinez R.;Granell M.;Vivo J. T.;Ruiz C. S.;Ibanez J. A. D. A.;Pastor E.;Soro M.;Ferrando C.;Defez M.;Alvares-Santullano C. A.;Perez R.;Rico J.;Jawad M.;Saeed Y.;Gillberg L.;Bengisun Z. K.;Kazbek B. K.;Coskunfirat N.;Boztug N.;Sanli S.;Yilmaz M.;Hadimioglu N.;Senturk N. M.;Camci E.;Kucukgoncu S.;Sungur Z.;Sivrikoz N.;Ozgen S. U.;Toraman F.;Selvi O.;Senturk O.;Yildiz M.;Kuvaki B.;Gunenc F.;Kucukguclu S.;Ozbilgin;Maral J.;Canli S.;Arun O.;Saltali A.;Aydogan E.;Akgun F. N.;Sanlikarip C.;Karaman F. M.;Mazur A.;Vorotyntsev S.;Rousseau G.;Barrett C.;Stancombe L.;Shelley B.;Scholes H.;Limb J.;Rafi A.;Wayman L.;Deane J.;Rogerson D.;Williams J.;Yates S.;Rogers E.;Pulletz M.;Moreton S.;Jones S.;Venkatesh S.;Burton M.;Brown L.;Goodall C.;Rucklidge M.;Fuller D.;Nadolski M.;Kusre S.;Lundberg M.;Everett L.;Nutt H.;Zuleika M.;Carvalho P.;Clements D.;Creagh-Brown B.;Watt P.;Raymode P.;Pearse R.;Mohr O.;Raj A.;Creary T.;Chishti A.;Bell A.;Higham C.;Cain A.;Gibb S.;Mowat S.;Franklin D.;West C.;Minto G.;Boyd N.;Mills G.;Calton E.;Walker R.;Mackenzie F.;Ellison B.;Roberts H.;Chikungwa M.;Jackson C.;Donovan A.;Foot J.;Homan E.;Montgomery J.;Portch D.;Mercer P.;Palmer J.;Paddle J.;Fouracres A.;Datson A.;Andrew A.;Welch L.;Rose A.;Varma S.;Simeson K.;Rambhatla M.;Susarla J.;Marri S.;Kodaganallur K.;Das A.;Algarsamy S.;Colley J.;Davies S.;Szewczyk M.;Smith T.;Fernandez-Bustamante A.;Luzier E.;Almagro A.;Melo M. V.;Fernando L.;Sulemanji D.;Sprung J.;Weingarten T.;Kor D.;Scavonetto F.;Tze Y.
2025-01-01
Abstract
Introduction: While smoking has been consistently identified as a significant contributor to postoperative complications, the existing literature on its association with postoperative pulmonary complications remains conflicting. Aim: We examined the association of preoperative smoking with the occurrence of postoperative pulmonary complications (PPCs). Methods: Post hoc analysis of an observational study in 146 hospitals across 29 countries. We included patients at increased risk of PPCs, according to the Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score (≥ 26 points). The primary endpoint was the occurrence of one or more predefined PPCs in the first five postoperative days, including unplanned postoperative need for supplementary oxygen, respiratory failure, unplanned need for invasive ventilation, ARDS, pneumonia and pneumothorax. Secondary endpoints included length of hospital stay and in–hospital mortality. We performed propensity score matching to correct for factors with a known association with postoperative outcomes. Results: Out of 2632 patients, 531 (20.2 %) patients were smokers and 2102 (79.8 %) non-smokers. At five days after surgery, 101 (19.0 %) smokers versus 404 (19.2) non–smokers had developed one or more PPCs (P = 0.95). Respiratory failure was more common in smokers (5.1 %) than non–smokers (3.0 %) (P = 0.02), while rates of other PPCs like need for supplementary oxygen, invasive ventilation, ARDS, pneumonia, or pneumothorax did not differ between the groups. Length of hospital stay and mortality was not different between groups. Propensity score matching did not change the findings. Conclusion: The occurrence of PPCs in smokers is not different from non–smokers. Funding: This analysis was performed without additional funding. LAS VEGAS was partially funded and endorsed by the European Society of Anaesthesiology through their Clinical Trial Network and the Amsterdam University Medical Centers, Amsterdam, The Netherlands. Registration: LAS VEGAS was registered at Clinicaltrials.gov (NCT01601223). Prior presentation: Preliminary study results have been presented at the Euroanaesthesia 2024 International Congress, in Munich, Germany.
Dorland, G.; Saadat, W.; Van Meenen, D. M. P.; Neto, A. S.; Hiesmayr, M.; Hollmann, M. W.; Mills, G. H.; Vidal Melo, M. F.; Putensen, C.; Schmid, W.; ...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2206534
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Il report seguente simula gli indicatori relativi alla propria produzione scientifica in relazione alle soglie ASN 2023-2025 del proprio SC/SSD. Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento dell'abilitazione. La simulazione si basa sui dati IRIS e sugli indicatori bibliometrici alla data indicata e non tiene conto di eventuali periodi di congedo obbligatorio, che in sede di domanda ASN danno diritto a incrementi percentuali dei valori. La simulazione può differire dall'esito di un’eventuale domanda ASN sia per errori di catalogazione e/o dati mancanti in IRIS, sia per la variabilità dei dati bibliometrici nel tempo. Si consideri che Anvur calcola i valori degli indicatori all'ultima data utile per la presentazione delle domande.
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