Introduction. Chronic bacterial prostatitis is a persistent chronic infection whose treatment is difficult and relapse is not uncommon. The condition presents with a variety of symptoms (mainly local pain that is variable in origin and intensity). These symptoms often persist despite eradication of the bacteria. The aim of this study is to examine the role of acid-forming agents as adjunctive therapy in patients with bacterial prostatitis. Materials and Methods. The material consisted of individuals with reported pelvic discomfort and genital pain with or without lower urinary tract symptoms and sexual dysfunction who visited our department from 03/2025 to 01/2026. Patients in whom the diagnosis was confirmed by the Stamey-Meares test (or alternatively by the two-glass test) were randomized into two groups. The first group (11 patients) received appropriate antibiotics (according to susceptibility testing) for 30 days, while the second group (8 patients) received a combination of acidifying agents, in addition to conventional antibiotic treatment for 30 days. The response was monitored using laboratory and clinical criteria. Results. We found statistically significant differences between the two groups in terms of the percentage of bacterial presence and persistence of symptoms, as well as the burden of symptoms in patients who received combination therapy. Conclusions. Acidifying agents improve the outcome of prostatitis treatment. Further randomized, placebo- controlled studies are needed to document more secure conclusions.
The role of acidifiers in the treatment of chronic bacterial prostatitis
G. PerlettiUltimo
2025-01-01
Abstract
Introduction. Chronic bacterial prostatitis is a persistent chronic infection whose treatment is difficult and relapse is not uncommon. The condition presents with a variety of symptoms (mainly local pain that is variable in origin and intensity). These symptoms often persist despite eradication of the bacteria. The aim of this study is to examine the role of acid-forming agents as adjunctive therapy in patients with bacterial prostatitis. Materials and Methods. The material consisted of individuals with reported pelvic discomfort and genital pain with or without lower urinary tract symptoms and sexual dysfunction who visited our department from 03/2025 to 01/2026. Patients in whom the diagnosis was confirmed by the Stamey-Meares test (or alternatively by the two-glass test) were randomized into two groups. The first group (11 patients) received appropriate antibiotics (according to susceptibility testing) for 30 days, while the second group (8 patients) received a combination of acidifying agents, in addition to conventional antibiotic treatment for 30 days. The response was monitored using laboratory and clinical criteria. Results. We found statistically significant differences between the two groups in terms of the percentage of bacterial presence and persistence of symptoms, as well as the burden of symptoms in patients who received combination therapy. Conclusions. Acidifying agents improve the outcome of prostatitis treatment. Further randomized, placebo- controlled studies are needed to document more secure conclusions.
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