The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication

MORTARA, LORENZO;
2002

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.
CYTOTOXIC T-LYMPHOCYTES, AIDS, INDUCTION, CHALLENGE, REGIMEN, MONKEYS, GENE, CTL, REV
T. M., Allen; Mortara, Lorenzo; B., Moth; M., Liebl; P., Jing; B., Calore; M., Piekarczyk; R., Ruddersdorf; D. H., Oconnor; X., Wang; C. X., Wang; D. B., Allison; J. D., Altman; A., Sette; R., Desrosiers; G., Sutter; D. I., Watkins
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/4186
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