The fine specificity of the cellular immune response to Candida albicans (i.e., recognition of different antigenic components) between normal controls and human immunodeficiency virus-infected patients in various stages of disease was compared. C. albicans-specific T cells, enriched by antigen stimulation and interleukin-2 expansion, were challenged with antigenic fractions of different molecular weight obtained by SDS-gel fractionation of C. albicans extracts in the presence of autologous mononuclear cells as antigen-presenting cells. Proliferative responses showed similar patterns of reactivity between controls and category A and B seropositive subjects. Category C patients with concurrent C. albicans infections did not give rise to C. albicans-specific T cell lines, confirming the T cell defect. Patients without clinically evident C. albicans infection had a low but broad reactivity pattern of C. albicans-specific T cells. These results suggest that depletion of C. albicans-specific T cells, independent of their fine specificity, occurs along with disease progression.
|Data di pubblicazione:||1998|
|Titolo:||Recognition of antigenic clusters of Candida albicans by T lymphocytes from human immunodeficiency virus-infected persons.|
|Rivista:||THE JOURNAL OF INFECTIOUS DISEASES|
|Codice identificativo ISI:||WOS:000075153000026|
|Codice identificativo Scopus:||2-s2.0-17344370006|
|Codice identificativo Pubmed:||9697731|
|Appare nelle tipologie:||Articolo su Rivista|