We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.
|Data di pubblicazione:||1988|
|Titolo:||A highly conserved sequence on the short arm of chromosome 7 detects multiple polymorphisms.|
|Codice identificativo ISI:||WOS:A1988R375000006|
|Codice identificativo Scopus:||2-s2.0-0024270022|
|Appare nelle tipologie:||Articolo su Rivista|