We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.

A highly conserved sequence on the short arm of chromosome 7 detects multiple polymorphisms.

MASERATI, EMANUELA;
1988

Abstract

We have isolated a human DNA fragment (laboratory acronym G98) that detects related sequences in mammals, chicken and Drosophila DNAs. This sequence has been mapped to human chromosome 7 p14-p15 by in situ hybridization. Probe G98 recognizes an insertion-deletion type polymorphism, with allelic frequencies of about 0.5, which can be detected with at least six different restriction enzymes. A second polymorphism, which can be detected in human DNA digested with TaqI, is in non-complete linkage disequilibrium with the first polymorphism. About 70% of the individuals analysed have been found to be heterozygous at this locus.
Bardoni, B.; Guioli, S.; Maserati, Emanuela; Maraschio, P.; Camerino, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/6779
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