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EnglishBACKGROUND: Exhaled breath contains thousands of volatile organic compounds (VOCs) that could serve as biomarkers of lung disease. Electronic noses can distinguish VOC mixtures by pattern recognition. OBJECTIVE: We hypothesized that an electronic nose can discriminate exhaled air of patients with asthma from healthy controls, and between patients with different disease severities. METHODS: Ten young patients with mild asthma (25.1 +/- 5.9 years; FEV(1), 99.9 +/- 7.7% predicted), 10 young controls (26.8 +/- 6.4 years; FEV(1), 101.9 +/- 10.3), 10 older patients with severe asthma (49.5 +/- 12.0 years; FEV(1), 62.3 +/- 23.6), and 10 older controls (57.3 +/- 7.1 years; FEV(1), 108.3 +/- 14.7) joined a cross-sectional study with duplicate sampling of exhaled breath with an interval of 2 to 5 minutes. Subjects inspired VOC-filtered air by tidal breathing for 5 minutes, and a single expiratory vital capacity was collected into a Tedlar bag that was sampled by electronic nose (Cyranose 320) within 10 minutes. Smellprints were analyzed by linear discriminant analysis on principal component reduction. Cross-validation values (CVVs) were calculated. RESULTS: Smellprints of patients with mild asthma were fully separated from young controls (CVV, 100%; Mahalanobis distance [M-distance], 5.32), and patients with severe asthma could be distinguished from old controls (CVV, 90%; M-distance, 2.77). Patients with mild and severe asthma could be less well discriminated (CVV, 65%; M-distance, 1.23), whereas the 2 control groups were indistinguishable (CVV, 50%; M-distance, 1.56). The duplicate samples replicated these results. CONCLUSION: An electronic nose can discriminate exhaled breath of patients with asthma from controls but is less accurate in distinguishing asthma severities. CLINICAL IMPLICATION: These findings warrant validation of electronic noses in diagnosing newly presented patients with asthma.
| Autori: | |
| Data di pubblicazione: | 2007 |
| Titolo: | An electronic nose in the discrimination of patients with asthma and controls. |
| Rivista: | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY |
| Digital Object Identifier (DOI): | 10.1016/j.jaci.2007.05.043 |
| Codice identificativo ISI: | WOS:000250157700020 |
| Codice identificativo Scopus: | 2-s2.0-35148827504 |
| Codice identificativo Pubmed: | 17658592 |
| Parole Chiave: | asthma mild, asthma severe, biomarkers, diagnosis, electronic nose, exhaled breath, volatile organic compounds VOLATILE ORGANIC-COMPOUNDS, COMPOSITE VAPOR DETECTORS, LUNG-CANCER, EXHALED BREATH, CLINICAL-APPLICATION, |
| Appare nelle tipologie: | Articolo su Rivista |
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