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EnglishA reciprocal translocation (9;11) is often found in acute myeloid leukemia (AML), mostly of the M5a type. We report a case of a child with AML, in whom t(9;11) was observed at diagnosis as the sole structural abnormality, together with trisomies 19 and 21. The diagnosis was AML evolving from a myelodysplastic syndrome (MDS), and the blast morphology was undifferentiated. Chemotherapy failed to induce morphological remission and the patient's condition soon worsened. A subclone appeared and expanded during the course of the disease, with an additional unbalanced translocation (1;17) leading to trisomy of the long arm of chromosome 17 (17q). The data available from the literature on acquired anomalies involving 17q and our observation led us to postulate a specific link between the gain of 17q and complete chemoresistance.
| Autori: | |
| Data di pubblicazione: | 2001 |
| Titolo: | 17Q21-QTER TRYSOMY IS AN INDICATOR OF POOR PROGNOSIS IN ACUTE MYELOGENOUS LEUKAEMIA |
| Rivista: | CANCER GENETICS AND CYTOGENETICS |
| Codice identificativo ISI: | WOS:000166559100003 |
| Codice identificativo Scopus: | 2-s2.0-0035139966 |
| Appare nelle tipologie: | Articolo su Rivista |
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