17Q21-QTER TRYSOMY IS AN INDICATOR OF POOR PROGNOSIS IN ACUTE MYELOGENOUS LEUKAEMIA

Morerio, C.; Russo, I.; Rapella, A.; Leszl, A.; Basso, G.; Maserati, Emanuela; Pasquali, Francesco; Panarello, C.

A reciprocal translocation (9;11) is often found in acute myeloid leukemia (AML), mostly of the M5a type. We report a case of a child with AML, in whom t(9;11) was observed at diagnosis as the sole structural abnormality, together with trisomies 19 and 21. The diagnosis was AML evolving from a myelodysplastic syndrome (MDS), and the blast morphology was undifferentiated. Chemotherapy failed to induce morphological remission and the patient's condition soon worsened. A subclone appeared and expanded during the course of the disease, with an additional unbalanced translocation (1;17) leading to trisomy of the long arm of chromosome 17 (17q). The data available from the literature on acquired anomalies involving 17q and our observation led us to postulate a specific link between the gain of 17q and complete chemoresistance.

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Autori:	MORERIO C. RUSSO I. RAPELLA A. LESZL A. BASSO G. MASERATI, EMANUELA PASQUALI, FRANCESCO PANARELLO C. mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2001
Titolo:	17Q21-QTER TRYSOMY IS AN INDICATOR OF POOR PROGNOSIS IN ACUTE MYELOGENOUS LEUKAEMIA
Rivista:	CANCER GENETICS AND CYTOGENETICS
Codice identificativo ISI:	WOS:000166559100003
Codice identificativo Scopus:	2-s2.0-0035139966
Appare nelle tipologie:	Articolo su Rivista

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Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11383/1489248

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