Osteochondral defects are frequent, painful, debilitating and expensive to treat, often resulting in poor results. The goal of the present study was to synthesize and characterize a novel biocompatible and biodegradable hydrogel comprised of poly(ethylene glycol), gelatin, and genipin, and examine the hydrogel as an injectable biomaterial in combination with a cyanoacrylate-based surgical sealant for cartilage repair. An osteochondral knee defect was generated in 24 rats, then the hydrogel, with or without a surgical sealant, was injected into the defect and followed for 14 days. The results demonstrated that the hydrogel is biocompatible and biodegradable, and that the cyanoacrylate-based surgical sealant is a relatively safe option for maintaining the hydrogel in the defect. This is the first study describing a cyanoacrylate-based surgical sealant in combination with a polymer hydrogel for cartilage repair.

A novel injectable hydrogel in combination with a surgical sealant in a rat knee osteochondral defect model.

CHERUBINO, MARIO;
2009-01-01

Abstract

Osteochondral defects are frequent, painful, debilitating and expensive to treat, often resulting in poor results. The goal of the present study was to synthesize and characterize a novel biocompatible and biodegradable hydrogel comprised of poly(ethylene glycol), gelatin, and genipin, and examine the hydrogel as an injectable biomaterial in combination with a cyanoacrylate-based surgical sealant for cartilage repair. An osteochondral knee defect was generated in 24 rats, then the hydrogel, with or without a surgical sealant, was injected into the defect and followed for 14 days. The results demonstrated that the hydrogel is biocompatible and biodegradable, and that the cyanoacrylate-based surgical sealant is a relatively safe option for maintaining the hydrogel in the defect. This is the first study describing a cyanoacrylate-based surgical sealant in combination with a polymer hydrogel for cartilage repair.
2009
http://dx.doi.org/10.1007/s00167-009-0881-2
Animals; Bioc; Cartilage Diseases; Cartilage; Articular; Disease Models; Animal; Female; Hydrogel; Injections; Intra-Articular; Knee Injuries; Knee Joint; Rats; Tissue Adhesives; ompatible Materials
N. D., Miljkovic; Y., Lin; Cherubino, Mario; D., Minteer; K. G., Marra
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/1719456
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