Study objectives: This study wanted to evaluate the correlations between haematic cortisol levels and the craniofacial morphology in children with Obstructive Sleep Apnoea Syndrome (OSAS) in comparison with healthy children. Design/setting/patients. This is a case-control study. Children referring to the Paediatric Department, University of Insubria, Varese, in the period between 1st and 31st October 2011 for a history of disturbed sleep were evaluated and 28 children, compliant to our criteria, were enrolled in the study. Interventions: All patients underwent a full-night polysomnographic evaluation. Haematic cortisol levels were measured using a radioimmunoassay technique. An orthodontic evaluation and a cranial lateral cephalometric analysis were performed. Measurements and results: Haematic cortisol concentration at 2.00 am was found higher in OSAS patients than in controls (p<0.05). An increase in craniomandibular (p<0.05) and intermaxillar (p<0.01) angles indicated a high angle tendency in OSAS with a posterior rotation of the mandible. A retro-position of the mandible (p<0.05), an increased overjet (p<0.01) and a reduction of overbite (p<0.01) were also found. Conclusions: The altered hypothalamic-pituitary-adrenal activity and the craniofacial modification found are not enough to state if these conditions are causes rather than consequences of OSAS. Moreover cortisol and sleep fragmentation can cause a reduction of growth hormone secretion so it is possible that the alteration of facial morphology may also have a metabolic cause.

Hematic Cortisol and Craniofacial Morphology in Children with OSAS

CAPRIOGLIO, ALBERTO;MARINO, FRANCA;MANGANO, CARLO;COSENTINO, MARCO;NOSETTI, LUANA
2013

Abstract

Study objectives: This study wanted to evaluate the correlations between haematic cortisol levels and the craniofacial morphology in children with Obstructive Sleep Apnoea Syndrome (OSAS) in comparison with healthy children. Design/setting/patients. This is a case-control study. Children referring to the Paediatric Department, University of Insubria, Varese, in the period between 1st and 31st October 2011 for a history of disturbed sleep were evaluated and 28 children, compliant to our criteria, were enrolled in the study. Interventions: All patients underwent a full-night polysomnographic evaluation. Haematic cortisol levels were measured using a radioimmunoassay technique. An orthodontic evaluation and a cranial lateral cephalometric analysis were performed. Measurements and results: Haematic cortisol concentration at 2.00 am was found higher in OSAS patients than in controls (p<0.05). An increase in craniomandibular (p<0.05) and intermaxillar (p<0.01) angles indicated a high angle tendency in OSAS with a posterior rotation of the mandible. A retro-position of the mandible (p<0.05), an increased overjet (p<0.01) and a reduction of overbite (p<0.01) were also found. Conclusions: The altered hypothalamic-pituitary-adrenal activity and the craniofacial modification found are not enough to state if these conditions are causes rather than consequences of OSAS. Moreover cortisol and sleep fragmentation can cause a reduction of growth hormone secretion so it is possible that the alteration of facial morphology may also have a metabolic cause.
http://www.omicsgroup.org/journals/hematic-cortisol-and-craniofacial-morphology-in-children-with-osas-2167-0277-2-136.php?aid=19574
Cephalometrics; Children; Growth; Orthodontics; Paediatric; Sleep apnoea
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/1888125
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