As widely recognized, tumor growth entails a close and complex cross-talk among cancer cells and the surrounding tumor microenvironment. We recently described the human RNASET2 gene as one key player of such microenvironmental cross-talk. Indeed, the protein encoded by this gene is an extracellular RNase which is able to control cancer growth in a non-cell autonomous mode by inducing a sustained recruitment of immune-competent cells belonging to the monocyte/macrophage lineage within a growing tumor mass. Here, we asked whether this oncosuppressor gene is sensitive to stress challenges and whether it can trigger cell-intrinsic processes as well. Indeed, RNASET2 expression levels were consistently found to increase following stress induction. Moreover, changes in RNASET2 expression levels turned out to affect several cancer-related parameters in vitro in an ovarian cancer cell line model. Of note, a remarkable rearrangement of the actin cytoskeleton organization, together with changes in cell adhesion and motility, emerged as putative mechanisms by which such cell-autonomous role could occur. Altogether, these biological features allow to put forward the hypothesis that the RNASET2 protein can act as a molecular barrier for limiting the damages and tissue remodeling events occurring during the earlier step of cell transformation.
|Data di pubblicazione:||2015|
|Titolo:||Pleiotropic modes of action in tumor cells of RNASET2, an evolutionary highly conserved extracellular RNase|
|Codice identificativo ISI:||WOS:000354885300037|
|Codice identificativo Scopus:||2-s2.0-84928400988|
|Codice identificativo Pubmed:||25797262|
|Parole Chiave:||Microenvironment; Ovarian cancer; RNase; Stress response|
|Appare nelle tipologie:||Articolo su Rivista|