In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound

HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients.

CANDUCCI, FILIPPO;
2015-01-01

Abstract

In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/106 peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound
2015
HIV-1 DNA load; KPCR; Residual viraemia; Virological failure; Virological rebound
Gianotti, N.; Canducci, Filippo; Galli, L.; Cossarini, F.; Salpietro, S.; Poli, A.; Nozza, S.; Spagnuolo, V.; Clementi, M.; Sampaolo, M.; Ceresola, E. R.; Racca, S.; Lazzarin, A.; Castagna, A.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2010721
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