A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.

A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles

Ieronimo, Gabriella;Palmisano, Giovanni;Maspero, Angelo;MARZORATI, ALESSANDRO;SCAPINELLO, LUCA;Masciocchi, Norberto;CRAVOTTO, GIANCARLO;Penoni, Andrea
2018

Abstract

A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.
Ieronimo, Gabriella; Palmisano, Giovanni; Maspero, Angelo; Marzorati, Alessandro; Scapinello, Luca; Masciocchi, Norberto; Cravotto, Giancarlo; Barge, Alessandro; Simonetti, Marco; Ameta, Keshav Lalit; Nicholas, Kenneth M; Penoni, Andrea
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11383/2074868
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