A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.
A novel synthesis of N-hydroxy-3-aroylindoles and 3-aroylindoles
Ieronimo, Gabriella;Palmisano, Giovanni;Maspero, Angelo;MARZORATI, ALESSANDRO;SCAPINELLO, LUCA;Masciocchi, Norberto;CRAVOTTO, GIANCARLO;Penoni, Andrea
2018-01-01
Abstract
A straightforward indole synthesis via annulation of C-nitrosoaromatics with conjugated terminal alkynones was realised achieving a simple, highly regioselective, atom- and step economical access to 3-aroylindoles in moderate to good yields. Further functionalizations of indole scaffolds were investigated and an easy way to JWH-018, a synthetic cannabinoid, was achieved.
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