Increased ANKRD1 levels linked to gain of function mutations have been associated to total anomalous pulmonary venous return and adult cardiomyopathy occurrence in humans. The link between increased ANKRD1 level and cardiac structural and functional disease is not understood. To get insight into this problem, we have generated a gain of function ANKRD1 mouse model by overexpressing ANKRD1 in the myocardium.
Myocardial overexpression of ANKRD1 causes sinus venosus defects and progressive diastolic dysfunction
Cinquetti, Raffaella;Monti, Laura;Bruno, Daniele;Grimaldi, Annalisa;Taramelli, Roberto;Acquati, Francesco
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2020-01-01
Abstract
Increased ANKRD1 levels linked to gain of function mutations have been associated to total anomalous pulmonary venous return and adult cardiomyopathy occurrence in humans. The link between increased ANKRD1 level and cardiac structural and functional disease is not understood. To get insight into this problem, we have generated a gain of function ANKRD1 mouse model by overexpressing ANKRD1 in the myocardium.
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