The palladium-catalyzed aminoazidation of aminoalkenes yielding azidomethyl-substituted nitrogen-containing heterocycles was developed. The procedure requires oxidative conditions and occurs at room temperature in the presence of hydrogen peroxide and NaN3 as the azide source. These conditions provide selective exo-cyclization/azidation of the carbon−carbon double bond, furnishing a versatile approach toward five-, six-, and seven-membered heterocyclic rings.

Intramolecular Aminoazidation of Unactivated Terminal Alkenes by Palladium-Catalyzed Reactions with Hydrogen Peroxide as the Oxidant

Foschi Francesca;Loro Camilla;Sala Roberto;Broggini Gianluigi
2020-01-01

Abstract

The palladium-catalyzed aminoazidation of aminoalkenes yielding azidomethyl-substituted nitrogen-containing heterocycles was developed. The procedure requires oxidative conditions and occurs at room temperature in the presence of hydrogen peroxide and NaN3 as the azide source. These conditions provide selective exo-cyclization/azidation of the carbon−carbon double bond, furnishing a versatile approach toward five-, six-, and seven-membered heterocyclic rings.
2020
Foschi, FRANCESCA MADDALENA; Loro, Camilla; Sala, Roberto; Oble, Julie; Lo Presti, Leonardo; Beccalli, Egle; Poli, Giovanni; Broggini, Gianluigi...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11383/2087635
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