A versatile electrochemical method for the intramolecular aminobromination of alkenes has been developed. The method provides access to five-, six-, and seven-membered heterocycles by exploiting tetrabutylammonium bromide as an electrolyte and bromine source. The mild electrochemical generation of Br2 plausibly allows the formation of a cyclic bromonium intermediate, as supported by density functional theory calculations.
Electrochemical Intramolecular Aminobromination of Alkenes
Cartamina E.;Papis M.;Spanu D.;Broggini G.;Loro C.
2025-01-01
Abstract
A versatile electrochemical method for the intramolecular aminobromination of alkenes has been developed. The method provides access to five-, six-, and seven-membered heterocycles by exploiting tetrabutylammonium bromide as an electrolyte and bromine source. The mild electrochemical generation of Br2 plausibly allows the formation of a cyclic bromonium intermediate, as supported by density functional theory calculations.
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