statistiche ricercatore

SACCHI, SILVIA

Distribuzione geografica

Continente	#
NA - Nord America	11.143
EU - Europa	6.959
AS - Asia	4.585
SA - Sud America	678
Continente sconosciuto - Info sul continente non disponibili	168
AF - Africa	73
OC - Oceania	44
Totale	23.650

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Nazione	#
US - Stati Uniti d'America	10.881
IT - Italia	3.632
SG - Singapore	1.435
CN - Cina	1.084
UA - Ucraina	1.023
VN - Vietnam	647
BR - Brasile	579
SE - Svezia	556
TR - Turchia	548
HK - Hong Kong	514
FI - Finlandia	321
DE - Germania	294
IE - Irlanda	267
GB - Regno Unito	236
FR - Francia	209
RU - Federazione Russa	160
CA - Canada	148
IN - India	78
MX - Messico	67
JP - Giappone	62
BD - Bangladesh	57
CZ - Repubblica Ceca	49
AU - Australia	41
ES - Italia	32
NL - Olanda	31
AR - Argentina	30
PL - Polonia	29
ZA - Sudafrica	29
BE - Belgio	27
AT - Austria	24
IQ - Iraq	24
EC - Ecuador	22
PK - Pakistan	22
CO - Colombia	19
EU - Europa	18
ID - Indonesia	18
LT - Lituania	14
CH - Svizzera	13
NG - Nigeria	13
AE - Emirati Arabi Uniti	10
IL - Israele	10
CL - Cile	9
JM - Giamaica	9
JO - Giordania	8
AZ - Azerbaigian	7
KE - Kenya	7
MA - Marocco	7
MD - Moldavia	7
MY - Malesia	7
CR - Costa Rica	6
KR - Corea	6
NP - Nepal	6
SA - Arabia Saudita	6
VE - Venezuela	6
NI - Nicaragua	5
RO - Romania	5
TT - Trinidad e Tobago	5
UZ - Uzbekistan	5
BG - Bulgaria	4
BO - Bolivia	4
DZ - Algeria	4
GE - Georgia	4
KZ - Kazakistan	4
PY - Paraguay	4
AL - Albania	3
CU - Cuba	3
GR - Grecia	3
HU - Ungheria	3
MT - Malta	3
PA - Panama	3
PE - Perù	3
PH - Filippine	3
PR - Porto Rico	3
PS - Palestinian Territory	3
PT - Portogallo	3
SV - El Salvador	3
CI - Costa d'Avorio	2
EG - Egitto	2
ET - Etiopia	2
GT - Guatemala	2
HN - Honduras	2
LK - Sri Lanka	2
LV - Lettonia	2
NO - Norvegia	2
NZ - Nuova Zelanda	2
OM - Oman	2
SK - Slovacchia (Repubblica Slovacca)	2
SN - Senegal	2
SY - Repubblica araba siriana	2
TN - Tunisia	2
AG - Antigua e Barbuda	1
AM - Armenia	1
AO - Angola	1
BH - Bahrain	1
BJ - Benin	1
BN - Brunei Darussalam	1
BS - Bahamas	1
BY - Bielorussia	1
CY - Cipro	1
DK - Danimarca	1
Totale	23.482

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Città	#
Milan	2.443
Fairfield	966
San Jose	934
Ashburn	873
Jacksonville	804
Singapore	750
Chandler	698
Woodbridge	635
Hong Kong	509
Seattle	395
Wilmington	392
Houston	359
Como	353
Council Bluffs	324
Ann Arbor	318
Dearborn	302
Princeton	297
Nyköping	295
Beijing	291
Cambridge	286
Dublin	263
Izmir	263
Dallas	225
The Dalles	214
Boardman	184
Dong Ket	181
Rome	161
Lauterbourg	135
Chicago	120
New York	110
Ho Chi Minh City	107
Los Angeles	98
San Mateo	86
Helsinki	84
Hanoi	73
Orem	72
San Diego	69
Santa Clara	68
Toronto	66
Munich	64
Tokyo	56
Ogden	54
São Paulo	50
Guangzhou	44
Mexico City	40
Chennai	37
Hefei	36
Kocaeli	36
London	35
Washington	35
Varese	33
Denver	32
Nanjing	30
Brussels	27
Olomouc	27
Warsaw	27
Brooklyn	26
Phoenix	26
Montreal	24
Redmond	23
Kunming	22
Manchester	22
Poplar	22
Amsterdam	21
Atlanta	21
Düsseldorf	21
Frankfurt am Main	21
Shanghai	21
Brno	20
Johannesburg	19
Rio de Janeiro	19
San Francisco	19
Turku	19
Haiphong	18
Norwalk	17
Tianjin	17
Verona	17
Da Nang	16
Boston	15
Bursa	15
Ankara	14
Columbus	14
Hangzhou	14
Mumbai	14
Redwood City	14
Shenzhen	14
Vienna	14
Belo Horizonte	13
Nanchang	13
Nuremberg	13
Stockholm	13
Abuja	12
Changsha	12
Dhaka	12
Gavirate	12
Jinan	12
Brasília	11
Buffalo	10
Fuzhou	10
Wenzhou	10
Totale	16.198

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Nome	#
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.	392
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.	283
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs	279
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging	265
Biosensors for D-amino acid detection	258
Structure-function relationships in human D-amino acid oxidase.	257
Effect of ligand binding on human D-amino acid oxidase: Implications for the development of new drugs for schizophrenia treatment	250
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia	241
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	233
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex.	227
Human d-amino acid oxidase: The inactive G183R variant	226
Characterization of human D-amino acid oxidase	225
A biosensor for all D-amino acids using evolved D-amino acid oxidase	224
Determination of D-amino acids using a D-amino acid oxidase biosensor with spectrophotometric and potentiometric detection	215
G72 primate-specific gene: a still enigmatic element in psychiatric disorders	215
Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients	215
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy	212
Relevance of weak flavin binding in human D-amino acid oxidase	209
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.	208
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity	208
Biochemical properties of human D-amino acid oxidase	208
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	207
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	207
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line	207
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients	205
Human D-Amino Acid Oxidase: Structure, Function, and Regulation	200
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	199
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility	199
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction	198
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity	193
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	190
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor	190
Is rat an appropriate animal model to study the involvement of d-serine catabolism in schizophrenia? insights from characterization of d-amino acid oxidase.	189
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period	189
Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies	187
Active site of yeast D-amino acid oxidase: mutations and inferences	186
The Freshwater Cyanobacterium Leptolymbya sp. FP1: PSP Toxins detection and genetic identification	185
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	185
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	185
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	185
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	183
Novel insights into renal d-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo	183
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon	180
Cellular studies on human D-aspartate oxidase	180
Active site of yeast D-amino acid oxidase:mutations and inferences	177
Physiological functions of D-amino acid oxidases: from yeast to humans.	176
The freshwater cyanobacterium Planktothrix SP.FP1: molecular identification and detection of paralytic shellfish poisoning toxins	176
Engineering the Properties of D-Amino Acid Oxidases by a Rational and a Directed Evolution Approach.	175
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus	175
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses	175
Deepening into the modulation of human D-amino acid oxidase	169
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	167
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex	167
Could D-serine serum levels be considered a biomarker in Alzheimer’s disease?	167
Role of human DAAO in D-serine metabolism: new insight	167
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers	165
Characterization of human DAAO variants potentially related to an increased risk to schizophrenia	164
Modulation of the activity and stability of human D-amino acid oxidase by the interaction with small ligands.	164
... And now saxitoxin-producing cyanobacteria in Europe	163
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity	160
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	159
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin	159
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.	158
Structural basis of D-aspartate oxidase properties	158
D-amino acid oxidase variants related to human pathologies	157
D-Serine metabolism in the brain: the role of D-amino acid oxidase	155
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	154
Engineering the substrate specificity of D-amino-acid oxidase	152
Serum D-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker	152
Metabolism of the neuromodulator D-serine	149
Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota	149
Biochemical characterization of mouse D-aspartate oxidase	149
Evolution of novel enzyme specificities from a common scaffold	148
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase	148
Biocatalysis and biocatalyst production	147
Detection of D-amino acids by D-amino acid oxidase.	146
Characterization of the G183R inactive human D-amino acid oxidase variant	146
Toxic cyanobacterial blooms in lake Varese (Italy): a multidisciplinary approach	143
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	142
Insight into pLG72 and D-amino acid oxidase interaction	141
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	140
pLG72-mediated modulation of hDAAO functionality: an intriguing issue	140
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia	140
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	139
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	137
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	137
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	135
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	134
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	134
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	133
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	132
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	131
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	131
Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations	128
In vivo studies on the D-amino acid oxidase-pLG72 interaction in human brain	128
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	127
Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism	126
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	125
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	125
Novel drugs for schizophrenia treatment: the mechanism of human D-amino acid oxidase inhibition	125
Totale	17.828

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Categoria	#
all - tutte	100.193
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	100.193

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2021/2022	1.268	0	197	101	77	101	36	94	107	72	179	120	184
2022/2023	1.898	170	89	153	213	154	441	7	240	253	76	47	55
2023/2024	3.695	592	590	630	653	720	219	15	48	93	31	17	87
2024/2025	2.594	14	46	387	91	140	163	140	229	310	242	280	552
2025/2026	5.897	410	289	256	788	607	385	1.179	366	677	484	253	203
2026/2027	411	176	235	0	0	0	0	0	0	0	0	0	0
Totale													23.650