statistiche ricercatore

SACCHI, SILVIA

Distribuzione geografica

Continente	#
NA - Nord America	10.329
EU - Europa	6.886
AS - Asia	4.459
SA - Sud America	665
AF - Africa	73
OC - Oceania	43
Continente sconosciuto - Info sul continente non disponibili	18
Totale	22.473

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Nazione	#
US - Stati Uniti d'America	10.140
IT - Italia	3.587
SG - Singapore	1.403
CN - Cina	1.028
UA - Ucraina	1.022
VN - Vietnam	645
BR - Brasile	575
TR - Turchia	548
SE - Svezia	546
HK - Hong Kong	510
FI - Finlandia	321
DE - Germania	294
IE - Irlanda	267
GB - Regno Unito	231
FR - Francia	207
RU - Federazione Russa	160
CA - Canada	112
IN - India	77
MX - Messico	65
JP - Giappone	58
CZ - Repubblica Ceca	49
AU - Australia	40
BD - Bangladesh	36
ES - Italia	30
NL - Olanda	29
ZA - Sudafrica	29
AR - Argentina	27
BE - Belgio	27
PL - Polonia	27
AT - Austria	24
IQ - Iraq	24
PK - Pakistan	22
EC - Ecuador	21
EU - Europa	18
ID - Indonesia	18
CO - Colombia	16
LT - Lituania	14
NG - Nigeria	13
CH - Svizzera	12
AE - Emirati Arabi Uniti	10
IL - Israele	10
CL - Cile	8
JO - Giordania	8
AZ - Azerbaigian	7
KE - Kenya	7
MA - Marocco	7
KR - Corea	6
VE - Venezuela	6
RO - Romania	5
SA - Arabia Saudita	5
UZ - Uzbekistan	5
BG - Bulgaria	4
BO - Bolivia	4
DZ - Algeria	4
GE - Georgia	4
KZ - Kazakistan	4
MD - Moldavia	4
MY - Malesia	4
NP - Nepal	4
PY - Paraguay	4
AL - Albania	3
CU - Cuba	3
GR - Grecia	3
HU - Ungheria	3
MT - Malta	3
PA - Panama	3
PH - Filippine	3
PS - Palestinian Territory	3
PT - Portogallo	3
CI - Costa d'Avorio	2
EG - Egitto	2
ET - Etiopia	2
LK - Sri Lanka	2
LV - Lettonia	2
NO - Norvegia	2
NZ - Nuova Zelanda	2
OM - Oman	2
PE - Perù	2
SK - Slovacchia (Repubblica Slovacca)	2
SN - Senegal	2
SY - Repubblica araba siriana	2
TN - Tunisia	2
TT - Trinidad e Tobago	2
AM - Armenia	1
AO - Angola	1
BH - Bahrain	1
BJ - Benin	1
BN - Brunei Darussalam	1
BY - Bielorussia	1
CY - Cipro	1
DK - Danimarca	1
DO - Repubblica Dominicana	1
EE - Estonia	1
GA - Gabon	1
GY - Guiana	1
HR - Croazia	1
IR - Iran	1
JM - Giamaica	1
KG - Kirghizistan	1
KI - Kiribati	1
Totale	22.464

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Città	#
Milan	2.439
Fairfield	966
Ashburn	827
Jacksonville	801
San Jose	793
Singapore	739
Chandler	698
Woodbridge	635
Hong Kong	505
Seattle	394
Wilmington	392
Houston	355
Como	353
Ann Arbor	318
Dearborn	302
Princeton	297
Nyköping	295
Cambridge	286
Beijing	275
Dublin	263
Izmir	263
Dallas	217
The Dalles	210
Boardman	183
Dong Ket	181
Rome	157
Lauterbourg	135
Chicago	117
Ho Chi Minh City	107
Council Bluffs	97
New York	96
Los Angeles	86
San Mateo	86
Helsinki	84
Hanoi	72
Orem	72
San Diego	68
Munich	64
Toronto	64
Tokyo	56
Ogden	54
São Paulo	48
Santa Clara	45
Guangzhou	44
Mexico City	39
Chennai	37
Hefei	36
Kocaeli	36
London	35
Washington	35
Nanjing	30
Denver	29
Brussels	27
Olomouc	27
Warsaw	27
Brooklyn	23
Redmond	23
Kunming	22
Manchester	22
Poplar	22
Amsterdam	21
Düsseldorf	21
Frankfurt am Main	21
Montreal	21
Brno	20
Phoenix	20
Varese	20
Atlanta	19
Johannesburg	19
Rio de Janeiro	19
Shanghai	19
Turku	19
Haiphong	18
Norwalk	17
San Francisco	17
Tianjin	17
Verona	17
Da Nang	16
Boston	15
Bursa	15
Ankara	14
Mumbai	14
Redwood City	14
Shenzhen	14
Vienna	14
Belo Horizonte	13
Nanchang	13
Nuremberg	13
Stockholm	13
Abuja	12
Changsha	12
Columbus	12
Gavirate	12
Hangzhou	12
Jinan	12
Brasília	11
Dhaka	10
Fuzhou	10
Wenzhou	10
Zhengzhou	10
Totale	15.625

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Nome	#
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.	362
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs	275
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.	266
Biosensors for D-amino acid detection	256
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging	256
Structure-function relationships in human D-amino acid oxidase.	235
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia	234
Effect of ligand binding on human D-amino acid oxidase: Implications for the development of new drugs for schizophrenia treatment	231
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	221
Human d-amino acid oxidase: The inactive G183R variant	221
A biosensor for all D-amino acids using evolved D-amino acid oxidase	217
Characterization of human D-amino acid oxidase	216
G72 primate-specific gene: a still enigmatic element in psychiatric disorders	212
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex.	209
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy	209
Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients	209
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.	208
Determination of D-amino acids using a D-amino acid oxidase biosensor with spectrophotometric and potentiometric detection	205
Relevance of weak flavin binding in human D-amino acid oxidase	205
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	204
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line	204
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	199
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity	197
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility	197
Human D-Amino Acid Oxidase: Structure, Function, and Regulation	195
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	193
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients	193
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction	192
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period	184
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	183
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity	183
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor	183
Biochemical properties of human D-amino acid oxidase	183
Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies	183
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	182
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	181
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	180
The Freshwater Cyanobacterium Leptolymbya sp. FP1: PSP Toxins detection and genetic identification	179
Is rat an appropriate animal model to study the involvement of d-serine catabolism in schizophrenia? insights from characterization of d-amino acid oxidase.	178
Active site of yeast D-amino acid oxidase: mutations and inferences	177
Novel insights into renal d-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo	177
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon	177
The freshwater cyanobacterium Planktothrix SP.FP1: molecular identification and detection of paralytic shellfish poisoning toxins	175
Cellular studies on human D-aspartate oxidase	173
Active site of yeast D-amino acid oxidase:mutations and inferences	172
Engineering the Properties of D-Amino Acid Oxidases by a Rational and a Directed Evolution Approach.	169
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus	169
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	167
Physiological functions of D-amino acid oxidases: from yeast to humans.	166
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses	166
Deepening into the modulation of human D-amino acid oxidase	164
Role of human DAAO in D-serine metabolism: new insight	163
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers	161
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex	159
Modulation of the activity and stability of human D-amino acid oxidase by the interaction with small ligands.	159
Could D-serine serum levels be considered a biomarker in Alzheimer’s disease?	159
Characterization of human DAAO variants potentially related to an increased risk to schizophrenia	158
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	157
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity	157
... And now saxitoxin-producing cyanobacteria in Europe	156
D-amino acid oxidase variants related to human pathologies	155
Structural basis of D-aspartate oxidase properties	155
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.	152
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	150
D-Serine metabolism in the brain: the role of D-amino acid oxidase	149
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin	148
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	147
Biochemical characterization of mouse D-aspartate oxidase	144
Metabolism of the neuromodulator D-serine	143
Evolution of novel enzyme specificities from a common scaffold	143
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase	143
Engineering the substrate specificity of D-amino-acid oxidase	142
Serum D-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker	142
Detection of D-amino acids by D-amino acid oxidase.	141
Toxic cyanobacterial blooms in lake Varese (Italy): a multidisciplinary approach	141
Biocatalysis and biocatalyst production	141
Characterization of the G183R inactive human D-amino acid oxidase variant	141
Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota	141
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	139
Insight into pLG72 and D-amino acid oxidase interaction	137
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	135
pLG72-mediated modulation of hDAAO functionality: an intriguing issue	135
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia	134
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	133
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	133
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	133
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	132
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	131
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	129
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	129
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	128
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	123
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	123
In vivo studies on the D-amino acid oxidase-pLG72 interaction in human brain	123
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	121
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	120
Cellular studies of the two main isoforms of human D-aspartate oxidase	120
Effect of binding of small ligands on the activity and stability of human D-amino acid oxidase:implications for the design of novel drugs for schizophrenia treatment	119
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	119
Toxic cyanobacterial blooms in Lake Varese: A multidisciplinary approach	119
Totale	17.134

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Categoria	#
all - tutte	91.131
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	91.131

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2020/2021	772	0	0	0	0	0	0	0	0	0	220	209	343
2021/2022	1.449	181	197	101	77	101	36	94	107	72	179	120	184
2022/2023	1.898	170	89	153	213	154	441	7	240	253	76	47	55
2023/2024	3.695	592	590	630	653	720	219	15	48	93	31	17	87
2024/2025	2.594	14	46	387	91	140	163	140	229	310	242	280	552
2025/2026	5.279	410	289	256	788	607	385	1.179	366	677	322	0	0
Totale													22.621