statistiche ricercatore

SACCHI, SILVIA

Distribuzione geografica

Continente	#
NA - Nord America	10.795
EU - Europa	6.917
AS - Asia	4.542
SA - Sud America	666
AF - Africa	73
OC - Oceania	44
Continente sconosciuto - Info sul continente non disponibili	18
Totale	23.055

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Nazione	#
US - Stati Uniti d'America	10.569
IT - Italia	3.611
SG - Singapore	1.422
CN - Cina	1.062
UA - Ucraina	1.022
VN - Vietnam	645
BR - Brasile	575
TR - Turchia	548
SE - Svezia	546
HK - Hong Kong	514
FI - Finlandia	321
DE - Germania	294
IE - Irlanda	267
GB - Regno Unito	235
FR - Francia	207
RU - Federazione Russa	160
CA - Canada	134
IN - India	78
MX - Messico	66
JP - Giappone	62
BD - Bangladesh	52
CZ - Repubblica Ceca	49
AU - Australia	41
ES - Italia	30
NL - Olanda	29
ZA - Sudafrica	29
AR - Argentina	27
BE - Belgio	27
PL - Polonia	27
AT - Austria	24
IQ - Iraq	24
EC - Ecuador	22
PK - Pakistan	22
EU - Europa	18
ID - Indonesia	18
CO - Colombia	16
LT - Lituania	14
NG - Nigeria	13
CH - Svizzera	12
AE - Emirati Arabi Uniti	10
IL - Israele	10
CL - Cile	8
JO - Giordania	8
AZ - Azerbaigian	7
KE - Kenya	7
MA - Marocco	7
MD - Moldavia	7
KR - Corea	6
MY - Malesia	6
NP - Nepal	6
SA - Arabia Saudita	6
VE - Venezuela	6
RO - Romania	5
UZ - Uzbekistan	5
BG - Bulgaria	4
BO - Bolivia	4
DZ - Algeria	4
GE - Georgia	4
JM - Giamaica	4
KZ - Kazakistan	4
PY - Paraguay	4
AL - Albania	3
CR - Costa Rica	3
CU - Cuba	3
GR - Grecia	3
HU - Ungheria	3
MT - Malta	3
PA - Panama	3
PH - Filippine	3
PS - Palestinian Territory	3
PT - Portogallo	3
TT - Trinidad e Tobago	3
CI - Costa d'Avorio	2
EG - Egitto	2
ET - Etiopia	2
LK - Sri Lanka	2
LV - Lettonia	2
NI - Nicaragua	2
NO - Norvegia	2
NZ - Nuova Zelanda	2
OM - Oman	2
PE - Perù	2
PR - Porto Rico	2
SK - Slovacchia (Repubblica Slovacca)	2
SN - Senegal	2
SV - El Salvador	2
SY - Repubblica araba siriana	2
TN - Tunisia	2
AM - Armenia	1
AO - Angola	1
BH - Bahrain	1
BJ - Benin	1
BN - Brunei Darussalam	1
BS - Bahamas	1
BY - Bielorussia	1
CY - Cipro	1
DK - Danimarca	1
DO - Repubblica Dominicana	1
EE - Estonia	1
GA - Gabon	1
Totale	23.041

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Città	#
Milan	2.442
Fairfield	966
San Jose	923
Ashburn	841
Jacksonville	801
Singapore	743
Chandler	698
Woodbridge	635
Hong Kong	509
Seattle	395
Wilmington	392
Houston	358
Como	353
Ann Arbor	318
Dearborn	302
Princeton	297
Nyköping	295
Cambridge	286
Beijing	284
Dublin	263
Izmir	263
Dallas	221
The Dalles	212
Council Bluffs	186
Boardman	183
Dong Ket	181
Rome	160
Lauterbourg	135
Chicago	118
New York	110
Ho Chi Minh City	107
Los Angeles	91
San Mateo	86
Helsinki	84
Hanoi	72
Orem	72
San Diego	69
Toronto	66
Munich	64
Tokyo	56
Ogden	54
Santa Clara	53
São Paulo	48
Guangzhou	44
Mexico City	40
Chennai	37
Hefei	36
Kocaeli	36
London	35
Washington	35
Denver	32
Nanjing	30
Brussels	27
Olomouc	27
Warsaw	27
Varese	25
Brooklyn	24
Montreal	24
Phoenix	24
Redmond	23
Kunming	22
Manchester	22
Poplar	22
Amsterdam	21
Düsseldorf	21
Frankfurt am Main	21
Atlanta	20
Brno	20
Johannesburg	19
Rio de Janeiro	19
Shanghai	19
Turku	19
Haiphong	18
San Francisco	18
Norwalk	17
Tianjin	17
Verona	17
Da Nang	16
Boston	15
Bursa	15
Ankara	14
Mumbai	14
Redwood City	14
Shenzhen	14
Vienna	14
Belo Horizonte	13
Columbus	13
Nanchang	13
Nuremberg	13
Stockholm	13
Abuja	12
Changsha	12
Gavirate	12
Hangzhou	12
Jinan	12
Brasília	11
Dhaka	10
Fuzhou	10
Wenzhou	10
Zhengzhou	10
Totale	15.942

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Nome	#
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.	374
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs	277
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.	272
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging	258
Biosensors for D-amino acid detection	256
Effect of ligand binding on human D-amino acid oxidase: Implications for the development of new drugs for schizophrenia treatment	241
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia	240
Structure-function relationships in human D-amino acid oxidase.	239
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	227
Characterization of human D-amino acid oxidase	225
Human d-amino acid oxidase: The inactive G183R variant	225
A biosensor for all D-amino acids using evolved D-amino acid oxidase	221
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex.	213
Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients	213
G72 primate-specific gene: a still enigmatic element in psychiatric disorders	212
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy	211
Determination of D-amino acids using a D-amino acid oxidase biosensor with spectrophotometric and potentiometric detection	210
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.	208
Relevance of weak flavin binding in human D-amino acid oxidase	207
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line	206
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	205
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity	205
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	202
Biochemical properties of human D-amino acid oxidase	202
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients	201
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility	199
Human D-Amino Acid Oxidase: Structure, Function, and Regulation	197
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	196
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction	196
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity	192
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	188
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period	186
Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies	186
The Freshwater Cyanobacterium Leptolymbya sp. FP1: PSP Toxins detection and genetic identification	184
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	184
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor	184
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	183
Is rat an appropriate animal model to study the involvement of d-serine catabolism in schizophrenia? insights from characterization of d-amino acid oxidase.	182
Active site of yeast D-amino acid oxidase: mutations and inferences	181
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	181
Novel insights into renal d-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo	181
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon	178
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	177
The freshwater cyanobacterium Planktothrix SP.FP1: molecular identification and detection of paralytic shellfish poisoning toxins	175
Active site of yeast D-amino acid oxidase:mutations and inferences	175
Cellular studies on human D-aspartate oxidase	174
Engineering the Properties of D-Amino Acid Oxidases by a Rational and a Directed Evolution Approach.	173
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus	172
Physiological functions of D-amino acid oxidases: from yeast to humans.	170
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses	170
Deepening into the modulation of human D-amino acid oxidase	166
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex	165
Role of human DAAO in D-serine metabolism: new insight	165
Could D-serine serum levels be considered a biomarker in Alzheimer’s disease?	164
Modulation of the activity and stability of human D-amino acid oxidase by the interaction with small ligands.	163
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers	163
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	162
Characterization of human DAAO variants potentially related to an increased risk to schizophrenia	161
... And now saxitoxin-producing cyanobacteria in Europe	159
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity	159
D-amino acid oxidase variants related to human pathologies	156
Structural basis of D-aspartate oxidase properties	156
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.	155
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin	155
D-Serine metabolism in the brain: the role of D-amino acid oxidase	154
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	152
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	150
Engineering the substrate specificity of D-amino-acid oxidase	148
Serum D-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker	148
Metabolism of the neuromodulator D-serine	147
Biochemical characterization of mouse D-aspartate oxidase	147
Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota	146
Evolution of novel enzyme specificities from a common scaffold	145
Biocatalysis and biocatalyst production	144
Characterization of the G183R inactive human D-amino acid oxidase variant	144
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase	144
Detection of D-amino acids by D-amino acid oxidase.	143
Toxic cyanobacterial blooms in lake Varese (Italy): a multidisciplinary approach	142
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	140
Insight into pLG72 and D-amino acid oxidase interaction	140
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	139
pLG72-mediated modulation of hDAAO functionality: an intriguing issue	138
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia	136
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	135
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	135
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	135
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	134
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	133
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	132
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	132
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	130
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	130
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	130
In vivo studies on the D-amino acid oxidase-pLG72 interaction in human brain	125
Biochemical Properties and Physiological Functions of pLG72: Twenty Years of Investigations	124
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	124
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	124
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	124
Novel drugs for schizophrenia treatment: the mechanism of human D-amino acid oxidase inhibition	123
Human D-aspartate Oxidase: A Key Player in D-aspartate Metabolism	123
Totale	17.503

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Categoria	#
all - tutte	96.543
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	96.543

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2020/2021	343	0	0	0	0	0	0	0	0	0	0	0	343
2021/2022	1.449	181	197	101	77	101	36	94	107	72	179	120	184
2022/2023	1.898	170	89	153	213	154	441	7	240	253	76	47	55
2023/2024	3.695	592	590	630	653	720	219	15	48	93	31	17	87
2024/2025	2.594	14	46	387	91	140	163	140	229	310	242	280	552
2025/2026	5.862	410	289	256	788	607	385	1.179	366	677	484	253	168
Totale													23.204