statistiche ricercatore

SACCHI, SILVIA

Distribuzione geografica

Continente	#
NA - Nord America	7.639
EU - Europa	6.101
AS - Asia	1.421
SA - Sud America	25
Continente sconosciuto - Info sul continente non disponibili	18
OC - Oceania	4
AF - Africa	3
Totale	15.211

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Nazione	#
US - Stati Uniti d'America	7.585
IT - Italia	3.533
UA - Ucraina	1.014
SE - Svezia	534
TR - Turchia	520
CN - Cina	368
VN - Vietnam	338
IE - Irlanda	264
FI - Finlandia	244
DE - Germania	215
SG - Singapore	142
GB - Regno Unito	128
CZ - Repubblica Ceca	49
FR - Francia	49
CA - Canada	47
JP - Giappone	23
BE - Belgio	18
EU - Europa	18
BR - Brasile	11
RU - Federazione Russa	11
CH - Svizzera	10
CO - Colombia	6
EC - Ecuador	6
HK - Hong Kong	6
PK - Pakistan	6
NL - Olanda	5
RO - Romania	5
ES - Italia	4
IL - Israele	4
IN - India	4
MX - Messico	4
BD - Bangladesh	3
CU - Cuba	3
GR - Grecia	3
AT - Austria	2
AU - Australia	2
BG - Bulgaria	2
HU - Ungheria	2
ID - Indonesia	2
LT - Lituania	2
NZ - Nuova Zelanda	2
PT - Portogallo	2
AE - Emirati Arabi Uniti	1
AR - Argentina	1
CL - Cile	1
EE - Estonia	1
HR - Croazia	1
IQ - Iraq	1
KE - Kenya	1
KR - Corea	1
LV - Lettonia	1
MA - Marocco	1
MY - Malesia	1
PL - Polonia	1
SA - Arabia Saudita	1
SK - Slovacchia (Repubblica Slovacca)	1
ZA - Sudafrica	1
Totale	15.211

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Città	#
Milan	2.433
Fairfield	966
Jacksonville	799
Chandler	698
Woodbridge	635
Ashburn	537
Seattle	391
Wilmington	391
Como	353
Houston	340
Ann Arbor	318
Dearborn	302
Princeton	297
Nyköping	295
Cambridge	286
Dublin	262
Izmir	262
Boardman	183
Dong Ket	181
Rome	155
Singapore	120
San Mateo	86
Beijing	85
San Diego	68
Ogden	54
Toronto	43
Chicago	40
Kocaeli	36
Washington	34
Hefei	32
Nanjing	29
Olomouc	27
Helsinki	26
Munich	25
Redmond	23
Tokyo	23
Kunming	22
Düsseldorf	21
Santa Clara	21
Brno	20
Brussels	18
Guangzhou	18
New York	18
London	17
Norwalk	17
Verona	17
Bursa	15
Redwood City	14
Dallas	13
Nanchang	13
Gavirate	12
Los Angeles	11
Jinan	10
Wenzhou	9
Changsha	8
Chengdu	7
Phoenix	7
Ponte Lambro	7
Zhengzhou	7
Falls Church	6
Fuzhou	6
Hebei	6
Hong Kong	6
Shenyang	6
Xian	6
Acton	5
Baotou	5
Barranquilla	5
Kilburn	5
Lugano	5
New Bedfont	5
Prescot	5
Augusta	4
Cairate	4
Chiswick	4
Frankfurt am Main	4
Islamabad	4
Petah Tikva	4
Shanghai	4
Timisoara	4
Varese	4
Besana in Brianza	3
Brighton	3
Casorezzo	3
Chongqing	3
Dhaka	3
Havana	3
Lappeenranta	3
Madrid	3
Parma	3
Pune	3
Samara	3
São Paulo	3
Trapani	3
Wandsworth	3
Wuhan	3
Amsterdam	2
Bergamo	2
Brasília	2
Budapest	2
Totale	11.317

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Nome	#
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs	229
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging	184
Biosensors for D-amino acid detection	182
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	181
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia	177
G72 primate-specific gene: a still enigmatic element in psychiatric disorders	177
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.	169
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction	163
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity	163
Human d-amino acid oxidase: The inactive G183R variant	163
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy	159
Novel insights into renal d-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo	156
Human D-Amino Acid Oxidase: Structure, Function, and Regulation	155
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.	154
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex.	153
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor	153
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility	153
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon	153
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients	153
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus	151
Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients	151
Characterization of human D-amino acid oxidase	150
Relevance of weak flavin binding in human D-amino acid oxidase	150
A biosensor for all D-amino acids using evolved D-amino acid oxidase	150
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period	148
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	147
Determination of D-amino acids using a D-amino acid oxidase biosensor with spectrophotometric and potentiometric detection	145
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.	144
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line	143
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	141
Structure-function relationships in human D-amino acid oxidase.	141
Is rat an appropriate animal model to study the involvement of d-serine catabolism in schizophrenia? insights from characterization of d-amino acid oxidase.	139
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity	139
Effect of ligand binding on human D-amino acid oxidase: Implications for the development of new drugs for schizophrenia treatment	139
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	138
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	137
Engineering the Properties of D-Amino Acid Oxidases by a Rational and a Directed Evolution Approach.	131
Physiological functions of D-amino acid oxidases: from yeast to humans.	130
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses	129
The freshwater cyanobacterium Planktothrix SP.FP1: molecular identification and detection of paralytic shellfish poisoning toxins	128
Modulation of the activity and stability of human D-amino acid oxidase by the interaction with small ligands.	128
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	128
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	127
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity	126
Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies	125
Biochemical properties of human D-amino acid oxidase	124
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	120
The Freshwater Cyanobacterium Leptolymbya sp. FP1: PSP Toxins detection and genetic identification	118
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	116
Toxic cyanobacterial blooms in lake Varese (Italy): a multidisciplinary approach	115
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers	115
Could D-serine serum levels be considered a biomarker in Alzheimer’s disease?	114
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.	114
Metabolism of the neuromodulator D-serine	112
Active site of yeast D-amino acid oxidase:mutations and inferences	111
Characterization of human DAAO variants potentially related to an increased risk to schizophrenia	110
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex	107
Evolution of novel enzyme specificities from a common scaffold	107
Active site of yeast D-amino acid oxidase: mutations and inferences	106
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	104
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia	104
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	103
Deepening into the modulation of human D-amino acid oxidase	103
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	102
Engineering the substrate specificity of D-amino-acid oxidase	101
D-amino acid oxidase variants related to human pathologies	101
Role of human DAAO in D-serine metabolism: new insight	99
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	98
Structural basis of D-aspartate oxidase properties	98
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	96
Glia-derived D-serine governs NMDA receptor-dependent synaptic activity in the prefrontal cortex.	96
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	94
Cellular studies on human D-aspartate oxidase	94
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	93
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	92
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	91
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	91
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	90
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	90
Characterization of the G183R inactive human D-amino acid oxidase variant	89
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	88
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	88
Rational design of a novel specificity of D-amino acid oxidase: towards the biosensor for all D-amino acids?	87
... And now saxitoxin-producing cyanobacteria in Europe	87
Insight into pLG72 and D-amino acid oxidase interaction	86
Role of R120 in the modulation of human D-amino acid oxidase	86
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	85
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	83
Effect of binding of small ligands on the activity and stability of human D-amino acid oxidase:implications for the design of novel drugs for schizophrenia treatment	82
Enzyme factory: engineering of new biocatalysts strating from a common scaffold	81
Ligand-induced conformational changes in human D-amino acid oxidase	80
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	79
D-Serine metabolism in the brain: the role of D-amino acid oxidase	79
Serum D-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker	79
Detection of D-amino acids by D-amino acid oxidase.	78
Ligand-induced conformational changes in human D-amino acid oxidase	78
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	78
Biocatalysis and biocatalyst production	77
pLG72-mediated modulation of hDAAO functionality: an intriguing issue	77
Toxic cyanobacterial blooms in Lake Varese: A multidisciplinary approach	77
Totale	12.035

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Categoria	#
all - tutte	58.348
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	58.348

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2019/2020	1.883	0	0	0	0	163	317	427	350	164	232	53	177
2020/2021	2.106	40	194	55	204	50	216	61	184	330	220	209	343
2021/2022	1.449	181	197	101	77	101	36	94	107	72	179	120	184
2022/2023	1.898	170	89	153	213	154	441	7	240	253	76	47	55
2023/2024	3.695	592	590	630	653	720	219	15	48	93	31	17	87
2024/2025	600	14	46	387	91	62	0	0	0	0	0	0	0
Totale													15.348