statistiche ricercatore

SACCHI, SILVIA

Distribuzione geografica

Continente	#
NA - Nord America	9.009
EU - Europa	6.580
AS - Asia	3.411
SA - Sud America	622
AF - Africa	42
Continente sconosciuto - Info sul continente non disponibili	18
OC - Oceania	5
Totale	19.687

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Nazione	#
US - Stati Uniti d'America	8.852
IT - Italia	3.569
SG - Singapore	1.088
UA - Ucraina	1.019
CN - Cina	658
BR - Brasile	555
SE - Svezia	545
TR - Turchia	543
VN - Vietnam	458
HK - Hong Kong	442
DE - Germania	274
FI - Finlandia	269
IE - Irlanda	267
GB - Regno Unito	201
RU - Federazione Russa	159
CA - Canada	105
FR - Francia	59
JP - Giappone	50
CZ - Repubblica Ceca	49
MX - Messico	44
IN - India	40
BE - Belgio	27
ES - Italia	24
PL - Polonia	24
AT - Austria	23
ZA - Sudafrica	22
BD - Bangladesh	21
AR - Argentina	20
EC - Ecuador	20
EU - Europa	18
IQ - Iraq	17
NL - Olanda	16
PK - Pakistan	16
ID - Indonesia	15
LT - Lituania	14
CH - Svizzera	12
CO - Colombia	12
IL - Israele	10
AE - Emirati Arabi Uniti	9
MA - Marocco	7
AZ - Azerbaigian	6
KR - Corea	6
RO - Romania	5
SA - Arabia Saudita	5
CL - Cile	4
BO - Bolivia	3
CU - Cuba	3
GR - Grecia	3
KE - Kenya	3
KZ - Kazakistan	3
MT - Malta	3
MY - Malesia	3
NP - Nepal	3
VE - Venezuela	3
AL - Albania	2
AU - Australia	2
BG - Bulgaria	2
DZ - Algeria	2
EG - Egitto	2
HU - Ungheria	2
LK - Sri Lanka	2
LV - Lettonia	2
NZ - Nuova Zelanda	2
OM - Oman	2
PA - Panama	2
PE - Perù	2
PS - Palestinian Territory	2
PT - Portogallo	2
PY - Paraguay	2
SK - Slovacchia (Repubblica Slovacca)	2
SN - Senegal	2
UZ - Uzbekistan	2
BH - Bahrain	1
BN - Brunei Darussalam	1
BY - Bielorussia	1
CI - Costa d'Avorio	1
DK - Danimarca	1
DO - Repubblica Dominicana	1
EE - Estonia	1
ET - Etiopia	1
GE - Georgia	1
GY - Guiana	1
HR - Croazia	1
IR - Iran	1
JO - Giordania	1
KG - Kirghizistan	1
KI - Kiribati	1
KW - Kuwait	1
MM - Myanmar	1
MN - Mongolia	1
NG - Nigeria	1
NI - Nicaragua	1
NO - Norvegia	1
RS - Serbia	1
SY - Repubblica araba siriana	1
TN - Tunisia	1
TT - Trinidad e Tobago	1
Totale	19.687

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Città	#
Milan	2.433
Fairfield	966
Jacksonville	801
Ashburn	709
Chandler	698
Woodbridge	635
Singapore	550
Hong Kong	441
Seattle	393
Wilmington	392
Como	353
Houston	352
Ann Arbor	318
Dearborn	302
Princeton	297
Nyköping	295
Cambridge	286
Dublin	263
Izmir	263
Beijing	243
Dallas	214
Boardman	183
Dong Ket	181
The Dalles	161
Rome	156
San Mateo	86
New York	85
Los Angeles	76
San Diego	68
Chicago	65
Munich	63
Toronto	62
Ogden	54
Tokyo	50
Ho Chi Minh City	43
São Paulo	43
Santa Clara	38
Kocaeli	36
Hefei	34
London	34
Washington	34
Helsinki	32
Hanoi	30
Nanjing	30
Brussels	27
Olomouc	27
Mexico City	26
Denver	25
Warsaw	24
Redmond	23
Kunming	22
Brooklyn	21
Düsseldorf	21
Brno	20
Council Bluffs	20
Guangzhou	20
Orem	20
Poplar	20
Montreal	19
Phoenix	19
Turku	19
Rio de Janeiro	18
Atlanta	17
Chennai	17
Norwalk	17
Varese	17
Verona	17
Bursa	15
Johannesburg	15
Redwood City	14
San Francisco	14
Belo Horizonte	13
Boston	13
Nanchang	13
Vienna	13
Columbus	12
Gavirate	12
Manchester	12
Stockholm	12
Nuremberg	11
Amsterdam	10
Brasília	10
Frankfurt am Main	10
Jinan	10
Shanghai	10
Ankara	9
Changsha	9
Curitiba	9
Wenzhou	9
Fuzhou	8
Haiphong	8
Zhengzhou	8
Chengdu	7
Des Moines	7
Guayaquil	7
Jakarta	7
Juiz de Fora	7
Ponte Lambro	7
Querétaro	7
Baghdad	6
Totale	13.658

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Nome	#
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.	313
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs	254
Biosensors for D-amino acid detection	238
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging	234
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia	215
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	211
Human d-amino acid oxidase: The inactive G183R variant	205
A biosensor for all D-amino acids using evolved D-amino acid oxidase	202
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.	201
G72 primate-specific gene: a still enigmatic element in psychiatric disorders	199
Characterization of human D-amino acid oxidase	196
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy	192
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line	192
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.	191
Relevance of weak flavin binding in human D-amino acid oxidase	189
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	188
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	187
Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients	186
Determination of D-amino acids using a D-amino acid oxidase biosensor with spectrophotometric and potentiometric detection	184
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility	183
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction	182
Human D-Amino Acid Oxidase: Structure, Function, and Regulation	182
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	180
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity	177
Effect of ligand binding on human D-amino acid oxidase: Implications for the development of new drugs for schizophrenia treatment	177
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex.	173
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity	172
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period	172
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients	171
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon	170
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	169
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	169
Structure-function relationships in human D-amino acid oxidase.	169
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor	169
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	167
Novel insights into renal d-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo	166
Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies	166
Is rat an appropriate animal model to study the involvement of d-serine catabolism in schizophrenia? insights from characterization of d-amino acid oxidase.	163
Biochemical properties of human D-amino acid oxidase	162
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus	161
The Freshwater Cyanobacterium Leptolymbya sp. FP1: PSP Toxins detection and genetic identification	160
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	159
Engineering the Properties of D-Amino Acid Oxidases by a Rational and a Directed Evolution Approach.	156
Active site of yeast D-amino acid oxidase: mutations and inferences	155
Active site of yeast D-amino acid oxidase:mutations and inferences	155
Cellular studies on human D-aspartate oxidase	154
Physiological functions of D-amino acid oxidases: from yeast to humans.	151
The freshwater cyanobacterium Planktothrix SP.FP1: molecular identification and detection of paralytic shellfish poisoning toxins	151
Role of human DAAO in D-serine metabolism: new insight	150
Modulation of the activity and stability of human D-amino acid oxidase by the interaction with small ligands.	148
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses	147
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex	146
Could D-serine serum levels be considered a biomarker in Alzheimer’s disease?	146
Characterization of human DAAO variants potentially related to an increased risk to schizophrenia	145
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	142
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity	142
Deepening into the modulation of human D-amino acid oxidase	140
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	138
D-amino acid oxidase variants related to human pathologies	138
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	135
... And now saxitoxin-producing cyanobacteria in Europe	135
Structural basis of D-aspartate oxidase properties	133
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers	132
Toxic cyanobacterial blooms in lake Varese (Italy): a multidisciplinary approach	130
Metabolism of the neuromodulator D-serine	129
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.	129
Biochemical characterization of mouse D-aspartate oxidase	128
D-Serine metabolism in the brain: the role of D-amino acid oxidase	127
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	126
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	126
Evolution of novel enzyme specificities from a common scaffold	126
pLG72-mediated modulation of hDAAO functionality: an intriguing issue	125
Detection of D-amino acids by D-amino acid oxidase.	124
Engineering the substrate specificity of D-amino-acid oxidase	124
Biocatalysis and biocatalyst production	123
Characterization of the G183R inactive human D-amino acid oxidase variant	123
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase	122
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	120
Insight into pLG72 and D-amino acid oxidase interaction	119
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin	119
Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota	118
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia	116
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	113
Serum D-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker	113
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	112
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	112
In vivo studies on the D-amino acid oxidase-pLG72 interaction in human brain	110
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	110
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	109
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	109
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	108
Glia-derived D-serine governs NMDA receptor-dependent synaptic activity in the prefrontal cortex.	108
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	108
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	107
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	107
Deepen human D-amino acid oxidase properties to get insight in D-serine metabolism.	107
Cellular studies of the two main isoforms of human D-aspartate oxidase	106
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	105
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	105
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	104
Totale	15.242

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Categoria	#
all - tutte	85.864
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	85.864

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2020/2021	1.563	0	0	0	0	0	216	61	184	330	220	209	343
2021/2022	1.449	181	197	101	77	101	36	94	107	72	179	120	184
2022/2023	1.898	170	89	153	213	154	441	7	240	253	76	47	55
2023/2024	3.695	592	590	630	653	720	219	15	48	93	31	17	87
2024/2025	2.594	14	46	387	91	140	163	140	229	310	242	280	552
2025/2026	2.492	410	289	256	788	607	142	0	0	0	0	0	0
Totale													19.834