statistiche ricercatore

SACCHI, SILVIA

Distribuzione geografica

Continente	#
NA - Nord America	9.104
EU - Europa	6.588
AS - Asia	3.474
SA - Sud America	628
AF - Africa	43
Continente sconosciuto - Info sul continente non disponibili	18
OC - Oceania	5
Totale	19.860

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Nazione	#
US - Stati Uniti d'America	8.940
IT - Italia	3.569
SG - Singapore	1.139
UA - Ucraina	1.019
CN - Cina	661
BR - Brasile	561
SE - Svezia	546
TR - Turchia	544
VN - Vietnam	458
HK - Hong Kong	445
DE - Germania	275
FI - Finlandia	269
IE - Irlanda	267
GB - Regno Unito	202
RU - Federazione Russa	159
CA - Canada	108
FR - Francia	59
JP - Giappone	51
CZ - Repubblica Ceca	49
MX - Messico	48
IN - India	42
BE - Belgio	27
PL - Polonia	27
ES - Italia	25
AT - Austria	24
ZA - Sudafrica	22
BD - Bangladesh	21
AR - Argentina	20
EC - Ecuador	20
EU - Europa	18
IQ - Iraq	17
NL - Olanda	16
PK - Pakistan	16
ID - Indonesia	15
LT - Lituania	14
CH - Svizzera	12
CO - Colombia	12
IL - Israele	10
AE - Emirati Arabi Uniti	9
MA - Marocco	7
AZ - Azerbaigian	6
KR - Corea	6
RO - Romania	5
SA - Arabia Saudita	5
CL - Cile	4
KE - Kenya	4
BO - Bolivia	3
CU - Cuba	3
GR - Grecia	3
JO - Giordania	3
KZ - Kazakistan	3
MT - Malta	3
MY - Malesia	3
NP - Nepal	3
VE - Venezuela	3
AL - Albania	2
AU - Australia	2
BG - Bulgaria	2
DZ - Algeria	2
EG - Egitto	2
HU - Ungheria	2
LK - Sri Lanka	2
LV - Lettonia	2
NZ - Nuova Zelanda	2
OM - Oman	2
PA - Panama	2
PE - Perù	2
PS - Palestinian Territory	2
PT - Portogallo	2
PY - Paraguay	2
SK - Slovacchia (Repubblica Slovacca)	2
SN - Senegal	2
UZ - Uzbekistan	2
BH - Bahrain	1
BN - Brunei Darussalam	1
BY - Bielorussia	1
CI - Costa d'Avorio	1
DK - Danimarca	1
DO - Repubblica Dominicana	1
EE - Estonia	1
ET - Etiopia	1
GE - Georgia	1
GY - Guiana	1
HR - Croazia	1
IR - Iran	1
KG - Kirghizistan	1
KI - Kiribati	1
KW - Kuwait	1
MM - Myanmar	1
MN - Mongolia	1
NG - Nigeria	1
NI - Nicaragua	1
NO - Norvegia	1
RS - Serbia	1
SY - Repubblica araba siriana	1
TN - Tunisia	1
TT - Trinidad e Tobago	1
Totale	19.860

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Città	#
Milan	2.433
Fairfield	966
Jacksonville	801
Ashburn	729
Chandler	698
Woodbridge	635
Singapore	596
Hong Kong	444
Seattle	394
Wilmington	392
Como	353
Houston	353
Ann Arbor	318
Dearborn	302
Princeton	297
Nyköping	295
Cambridge	286
Dublin	263
Izmir	263
Beijing	243
Dallas	215
Boardman	183
Dong Ket	181
The Dalles	161
Rome	156
New York	92
San Mateo	86
Los Angeles	83
San Diego	68
Chicago	65
Munich	63
Toronto	63
Ogden	54
Tokyo	51
São Paulo	46
Ho Chi Minh City	43
Council Bluffs	40
Santa Clara	39
Kocaeli	36
Hefei	34
London	34
Washington	34
Helsinki	32
Hanoi	30
Nanjing	30
Mexico City	29
Orem	28
Brussels	27
Denver	27
Olomouc	27
Warsaw	27
Redmond	23
Kunming	22
Brooklyn	21
Düsseldorf	21
Montreal	21
Poplar	21
Brno	20
Guangzhou	20
Phoenix	20
Turku	19
Atlanta	18
Chennai	18
Rio de Janeiro	18
Norwalk	17
Varese	17
Verona	17
Boston	15
Bursa	15
Johannesburg	15
Redwood City	14
San Francisco	14
Vienna	14
Belo Horizonte	13
Nanchang	13
Stockholm	13
Columbus	12
Gavirate	12
Manchester	12
Frankfurt am Main	11
Nuremberg	11
Amsterdam	10
Ankara	10
Brasília	10
Jinan	10
Shanghai	10
Changsha	9
Curitiba	9
Wenzhou	9
Fuzhou	8
Haiphong	8
Querétaro	8
Zhengzhou	8
Chengdu	7
Des Moines	7
Guayaquil	7
Jakarta	7
Juiz de Fora	7
Mumbai	7
Ponte Lambro	7
Totale	13.800

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Nome	#
Synaptic and extrasynaptic NMDA receptors are gated by different endogenous coagonists.	315
Structure-function relationships in human d-amino acid oxidase variants corresponding to known SNPs	255
Biosensors for D-amino acid detection	239
Age-Related Changes in D-Aspartate Oxidase Promoter Methylation Control Extracellular D-Aspartate Levels and Prevent Precocious Cell Death during Brain Aging	234
Characterization of human DAAO variants potentially related to an increased risk of schizophrenia	217
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	212
Human d-amino acid oxidase: The inactive G183R variant	206
Evidence for the interaction of d-amino acid oxidase with pLG72 in a glial cell line.	205
A biosensor for all D-amino acids using evolved D-amino acid oxidase	202
G72 primate-specific gene: a still enigmatic element in psychiatric disorders	199
Characterization of human D-amino acid oxidase	197
The degradation (by distinct pathways) of human D-amino acid oxidase and its interacting partner pLG72--two key proteins in D-serine catabolism in the brain.	193
Proline oxidase controls proline, glutamate, and glutamine cellular concentrations in a U87 glioblastoma cell line	193
D-amino acid oxidase inhibitors as a novel class of drugs for schizophrenia therapy	192
Relevance of weak flavin binding in human D-amino acid oxidase	191
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	189
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	187
Decreased free D-aspartate levels are linked to enhanced D-aspartate oxidase activity in the dorsolateral prefrontal cortex of schizophrenia patients	187
Determination of D-amino acids using a D-amino acid oxidase biosensor with spectrophotometric and potentiometric detection	186
Elucidating the role of the pLG72 R30K substitution in schizophrenia susceptibility	185
Effect of ligand binding on human D-amino acid oxidase: Implications for the development of new drugs for schizophrenia treatment	185
Regulating levels of the neuromodulator d-serine in human brain: structural insight into pLG72 and d-amino acid oxidase interaction	184
Human D-Amino Acid Oxidase: Structure, Function, and Regulation	183
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	180
Olanzapine, but not clozapine, increases glutamate release in the prefrontal cortex of freely moving mice by inhibiting D-aspartate oxidase activity	178
Structure-function relationships in human D-amino acid oxidase.	177
Glial D-Serine Gates NMDA Receptors at Excitatory Synapses in Prefrontal Cortex.	175
Reduced D-serine levels in the nucleus accumbens of cocaine-treated rats hinder the induction of NMDA receptor-dependent synaptic plasticity	174
D-Serine and Glycine Differentially Control Neurotransmission during Visual Cortex Critical Period	173
The levels of the NMDA receptor co-agonist D-serine are reduced in the substantia nigra of MPTP-lesioned macaques and in the cerebrospinal fluid of Parkinson’s disease patients	172
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	171
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	171
High-Throughput Screening Strategy Identifies Allosteric, Covalent Human D-Amino Acid Oxidase Inhibitor	171
Understanding renal nuclear protein accumulation: an in vitro approach to explain an in vivo phenomenon	171
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	169
Novel insights into renal d-amino acid oxidase accumulation: propiverine changes DAAO localization and peroxisomal size in vivo	167
Biochemical properties of human D-amino acid oxidase variants and their potential significance in pathologies	167
Is rat an appropriate animal model to study the involvement of d-serine catabolism in schizophrenia? insights from characterization of d-amino acid oxidase.	165
Identity of the NMDA receptor coagonist is synapse specific and developmentally regulated in the hippocampus	162
Biochemical properties of human D-amino acid oxidase	162
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	161
The Freshwater Cyanobacterium Leptolymbya sp. FP1: PSP Toxins detection and genetic identification	160
Engineering the Properties of D-Amino Acid Oxidases by a Rational and a Directed Evolution Approach.	157
Active site of yeast D-amino acid oxidase: mutations and inferences	155
Active site of yeast D-amino acid oxidase:mutations and inferences	155
Cellular studies on human D-aspartate oxidase	154
Physiological functions of D-amino acid oxidases: from yeast to humans.	152
The freshwater cyanobacterium Planktothrix SP.FP1: molecular identification and detection of paralytic shellfish poisoning toxins	152
Role of human DAAO in D-serine metabolism: new insight	152
Modulation of the activity and stability of human D-amino acid oxidase by the interaction with small ligands.	149
Co-agonists differentially tune GluN2B-NMDA receptor trafficking at hippocampal synapses	149
Glial D-serine gates NMDA receptors at excitatory synapses in prefrontal cortex	147
Could D-serine serum levels be considered a biomarker in Alzheimer’s disease?	147
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	146
Characterization of human DAAO variants potentially related to an increased risk to schizophrenia	146
Free D-aspartate triggers NMDA receptor-dependent cell death in primary cortical neurons and perturbs JNK activation, Tau phosphorylation, and protein SUMOylation in the cerebral cortex of mice lacking D-aspartate oxidase activity	144
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	141
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	141
Deepening into the modulation of human D-amino acid oxidase	140
D-amino acid oxidase variants related to human pathologies	139
... And now saxitoxin-producing cyanobacteria in Europe	138
Metabolic resistance of the D-peptide RD2 developed for direct elimination of amyloid-β oligomers	134
Structural basis of D-aspartate oxidase properties	133
Identity of endogenous NMDAR glycine site agonist in amygdala is determined by synaptic activity level.	132
Toxic cyanobacterial blooms in lake Varese (Italy): a multidisciplinary approach	131
Metabolism of the neuromodulator D-serine	130
D-Serine metabolism in the brain: the role of D-amino acid oxidase	129
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	128
Engineering the substrate specificity of D-amino-acid oxidase	128
Evolution of novel enzyme specificities from a common scaffold	128
Biochemical characterization of mouse D-aspartate oxidase	128
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	127
pLG72-mediated modulation of hDAAO functionality: an intriguing issue	127
Detection of D-amino acids by D-amino acid oxidase.	125
Biocatalysis and biocatalyst production	124
Characterization of the G183R inactive human D-amino acid oxidase variant	123
Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase	123
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	121
Insight into pLG72 and D-amino acid oxidase interaction	120
An antibody-based enzymatic therapy for cancer treatment: The selective localization of D-amino acid oxidase to EDA fibronectin	119
DNA methylation landscape of the genes regulating D-serine and D-aspartate metabolism in post-mortem brain from controls and subjects with schizophrenia	118
Antimicrobial D-amino acid oxidase-derived peptides specify gut microbiota	118
Serum D-serine levels are altered in early phases of Alzheimer’s disease: towards a precocious biomarker	116
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	114
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	114
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	113
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	112
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	110
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	110
In vivo studies on the D-amino acid oxidase-pLG72 interaction in human brain	110
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	109
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	109
Glia-derived D-serine governs NMDA receptor-dependent synaptic activity in the prefrontal cortex.	108
Deepen human D-amino acid oxidase properties to get insight in D-serine metabolism.	108
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	107
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	107
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	106
Cellular studies of the two main isoforms of human D-aspartate oxidase	106
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	105
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	104
Totale	15.380

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Categoria	#
all - tutte	86.361
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	86.361

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2020/2021	1.563	0	0	0	0	0	216	61	184	330	220	209	343
2021/2022	1.449	181	197	101	77	101	36	94	107	72	179	120	184
2022/2023	1.898	170	89	153	213	154	441	7	240	253	76	47	55
2023/2024	3.695	592	590	630	653	720	219	15	48	93	31	17	87
2024/2025	2.594	14	46	387	91	140	163	140	229	310	242	280	552
2025/2026	2.665	410	289	256	788	607	315	0	0	0	0	0	0
Totale													20.007