statistiche ricercatore

PILONE, MIRELLA

Distribuzione geografica

Continente	#
NA - Nord America	8.835
EU - Europa	6.897
AS - Asia	4.497
SA - Sud America	479
AF - Africa	61
Continente sconosciuto - Info sul continente non disponibili	18
OC - Oceania	17
Totale	20.804

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Nazione	#
US - Stati Uniti d'America	8.706
IT - Italia	3.401
SG - Singapore	1.334
UA - Ucraina	1.241
CN - Cina	1.036
TR - Turchia	765
VN - Vietnam	635
SE - Svezia	579
HK - Hong Kong	453
BR - Brasile	414
FI - Finlandia	377
DE - Germania	283
IE - Irlanda	252
FR - Francia	216
GB - Regno Unito	205
RU - Federazione Russa	155
IN - India	74
JP - Giappone	68
CA - Canada	62
MX - Messico	48
CZ - Repubblica Ceca	30
BD - Bangladesh	28
ES - Italia	27
ZA - Sudafrica	27
BE - Belgio	24
AR - Argentina	22
NL - Olanda	22
PL - Polonia	21
EU - Europa	17
IQ - Iraq	17
AU - Australia	15
LT - Lituania	13
CO - Colombia	12
PK - Pakistan	12
AT - Austria	9
EC - Ecuador	9
IL - Israele	9
CL - Cile	8
TN - Tunisia	8
CH - Svizzera	7
ID - Indonesia	7
VE - Venezuela	7
AE - Emirati Arabi Uniti	6
BG - Bulgaria	6
KE - Kenya	6
SA - Arabia Saudita	6
AZ - Azerbaigian	5
DZ - Algeria	5
JM - Giamaica	5
MA - Marocco	5
UZ - Uzbekistan	5
JO - Giordania	4
KZ - Kazakistan	4
LU - Lussemburgo	4
MD - Moldavia	4
MY - Malesia	4
PA - Panama	4
PH - Filippine	4
PT - Portogallo	4
SY - Repubblica araba siriana	4
CR - Costa Rica	3
EG - Egitto	3
HU - Ungheria	3
NG - Nigeria	3
RO - Romania	3
UY - Uruguay	3
AO - Angola	2
DO - Repubblica Dominicana	2
EE - Estonia	2
IR - Iran	2
LB - Libano	2
NP - Nepal	2
OM - Oman	2
PE - Perù	2
PR - Porto Rico	2
PY - Paraguay	2
RS - Serbia	2
AL - Albania	1
AM - Armenia	1
BH - Bahrain	1
BT - Bhutan	1
BY - Bielorussia	1
CY - Cipro	1
ET - Etiopia	1
GA - Gabon	1
GR - Grecia	1
GT - Guatemala	1
HR - Croazia	1
KG - Kirghizistan	1
KI - Kiribati	1
LK - Sri Lanka	1
LV - Lettonia	1
MK - Macedonia	1
MN - Mongolia	1
MO - Macao, regione amministrativa speciale della Cina	1
NI - Nicaragua	1
NZ - Nuova Zelanda	1
PS - Palestinian Territory	1
SK - Slovacchia (Repubblica Slovacca)	1
TT - Trinidad e Tobago	1
Totale	20.803

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Città	#
Milan	2.563
Jacksonville	925
San Jose	919
Chandler	789
Singapore	700
Ashburn	581
Fairfield	511
Hong Kong	451
Izmir	383
Woodbridge	326
Dearborn	318
Princeton	312
Nyköping	309
Beijing	295
Wilmington	293
Dublin	250
Seattle	211
Ann Arbor	201
Dallas	190
Houston	190
Dong Ket	185
Chicago	183
Rome	182
Cambridge	181
Boardman	173
The Dalles	170
San Mateo	145
Lauterbourg	137
Council Bluffs	126
Ho Chi Minh City	103
Como	79
Los Angeles	73
New York	73
Orem	67
Hanoi	63
Ogden	62
Tokyo	60
Guangzhou	55
Helsinki	50
São Paulo	47
Santa Clara	46
San Diego	45
Kocaeli	39
Chennai	36
Hefei	34
Nanjing	34
Munich	31
Düsseldorf	30
Kunming	28
London	28
Washington	27
Manchester	26
Verona	25
Brussels	24
Tianjin	24
Toronto	24
Mexico City	23
Atlanta	21
Shanghai	21
Warsaw	21
Johannesburg	20
Montreal	19
Nanchang	19
Denver	18
Amsterdam	17
Brooklyn	17
Frankfurt am Main	17
Norwalk	17
Hangzhou	16
Olomouc	16
Turku	16
Haiphong	15
Poplar	15
Shenzhen	15
Jinan	14
Boston	13
Da Nang	13
Redwood City	13
Brno	12
Belo Horizonte	11
Curitiba	11
Phoenix	11
Rio de Janeiro	11
San Francisco	11
Ankara	10
Fuzhou	10
Memphis	10
Mumbai	10
Stockholm	9
Chongqing	8
Des Moines	8
New Delhi	8
Zhengzhou	8
Shenyang	7
Wenzhou	7
Buenos Aires	6
Changsha	6
Columbus	6
Edinburgh	6
Falls Church	6
Totale	14.000

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Nome	#
Modulating D-amino acid oxidase substrate specificity: production of an enzyme for analytical determination of all D-amino acids by directed evolution	227
Characterization of human D-amino acid oxidase	225
A biosensor for all D-amino acids using evolved D-amino acid oxidase	221
Contribution of the dimeric state to the thermal stability of the flavoprotein D-amino acid oxidase	211
Relevance of weak flavin binding in human D-amino acid oxidase	207
Investigating the role of active site residues of Rhodotorula gracilis D-amino acid oxidase on its substrate specificity.	205
Catalytic properties of D-amino acid oxidase in cephalosporin C bioconversion: A comparison between proteins from different sources	202
Analyzing the d-amino acid content in biological samples by engineered enzymes	202
Dissecting the structural determinants of the stability of cholesterol oxidase containing covalently bound flavin	196
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase: a crystallographic and site-directed mutagenesis approach	196
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E.coli	188
Evolution of an acylase active on cephalosporin C	186
A "molten globule"-like intermediate in the unfolding of the peroxisomal flavoprotein D-amino acid oxidase	185
The role of tyrosines 223 and 238 in Rhodotorula gracilis D-amino acid oxidase catalysis: Interpretation of double mutations	184
Active site and reaction mechanism of Rhodotorula gracilis D-amino acid oxidase:a crystallographic and site-directed mutagenesis approach	183
Active site of yeast D-amino acid oxidase: mutations and inferences	181
Expression in Escherichia coli and in vitro refolding of the human protein pLG72	181
Yeast D-amino acid oxidase: structural basis of its catalytic properties	180
Role of tyrosine 238 in the active site of Rhodotorula gracilis D-amino acid oxidase - A site-directed mutagenesis study	177
Active site of yeast D-amino acid oxidase:mutations and inferences	175
Kinetic mechanisms of glycine oxidase from Bacillus subtilis	173
Tryptophan 243 affects interprotein contacts, cofactor binding and stability in D-amino acid oxidase from Rhodotorula gracilis	173
Characterization of a D-amino acid oxidase microbiosensor for D-serine detection in the central nervous system.	173
D-amino acid oxidase: new findings	172
The x-ray structure of D-amino acid oxidase at very high resolution identifies the chemical mechanism of flavin-dependent substrate dehydrogenation	170
Physiological functions of D-amino acid oxidases: from yeast to humans.	170
Yeast D-amino acid oxidase: Structural basis of its catalytic properties	169
Characterization of a yeast D-amino acid oxidase microbiosensor for D-serine detection in the central nervous system	168
Characterization of the new flavoprotein glycine oxidase from Bacillus subtilis	163
Yeast D-amino acid oxidase: structural basis of its catalytic properties	163
Glycine oxidase from Bacillus subtilis - Characterization of a new flavoprotein	162
Properties and applications of microbial D-amino acid oxidases: Current state and perspectives	162
A "molten globule" - like intermediate in the unfolding of the flavoprotein D-amino acid oxidase	160
Redox potentials and their pH dependence of D-amino-acid oxidase of Rhodotorula gracilis and Trigonopsis variabilis	158
On the oxygen reactivity of cholesterol oxidase.	156
Studies on the reaction mechanism of Rhodotorula gracilis D-amino-acid oxidase - Role of the highly conserved Tyr-223 on substrate binding and catalysis	156
Characterization of the new flavoprotein glycine oxidase from Bacillus subtilis	156
Ruolo della dimerizzazione nel flavoenzima D-amino acido ossidasi da Rhodotorula gracilis	156
Cholesterol oxidase from Brevibacterium sterolicum and Streptomices hygroscopicus: a covalent FAD binding vs. a non-covalent one	152
Glycine oxidase from Bacillus subtilis: Role of Histidine 244 and Methionine 261.	152
D-amino acid oxidase as an industrial biocatalyst	151
Regulation of D-amino acid oxidase expression in the yeast Rhodotorula gracilis	150
pLG72 modulates intracellular D-serine levels through its interaction with D-amino acid oxidase - Effect on schizophrenia susceptibility	150
Dissection of the structural determinants involved in formation of the dimeric form of D-amino acid oxidase from Rhodotorula gracilis: role of the size of the beta F5-beta F6 loop	149
Engineering the substrate specificity of D-amino-acid oxidase	148
Structure-function relationships in glycine oxidase from Bacillus subtilis	147
Evolution of a Cephalosporin C Acylase.	147
Effect of the oligomerization state on the thermal stability of yeast D-amino acid oxidase	146
Evolution of novel enzyme specificities from a common scaffold	145
Unfolding intermediate in the peroxisomal flavoprotein D-amino acid oxidase	145
Conversion of the dimeric D-amino acid oxidase from Rhodotorula gracilis to a monomeric form. A rational mutagenesis approach	144
Biocatalysis and biocatalyst production	144
Kinetic mechanisms of cholesterol oxidase from Streptomyces hygroscopicus and Brevibacterium sterolicum	143
Detection of D-amino acids by D-amino acid oxidase.	143
Cloning and characterization of human and Xenopus allantoicase	142
Structure and function of Rhodotorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosines 223 and 238	140
Investigating the metabolic role of glycine oxidase from Bacillus subtilis	140
Characterization of D-Amino Acid Oxidase Microbiosensor for D-Serina detection in the central nervous system.	140
Glycine oxiadse from Bacillus subtilis: role of the histidine 244 and methionine 261	139
On the mechanism of Rhodotorula gracilis D-amino acid oxidase: role of the active site serine 335	139
On the oxygen reactivity of flavoprotein oxidase. An oxygen access tunnel and gate in Brevibacterium sterolicum cholesterol oxidase.	139
Site-directed mutagenesis and thermodynamic studies reveal the role of dimeric oligomerization state in yeast D-amino acid oxidase	135
Engineering the substrate specificity of D-amino acid oxidase: a rational design approach	135
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	135
Characterization of human D-amino acid oxidase, a flavoenzyme involved in neurotransmission regulation	135
Cholesterol oxidase from Brevibacterium sterolicum and Streptomyces hygroscopicus: a covalent FAD binding vs. a non-covalent one	135
Role of the highly conserved Tyr223 and Tyr238 of yeast D-amino acid oxidase	134
Structure and function of Rhodothorula gracilis D-amino acid oxidase. 1. Site-directed mutagenesis of tyrosine 223 and 238	133
Very high resolution crystallographic structures of D-amino acid oxidase complexed with substrate and various ligands	132
Examination of pLG72 and D-Amino Acid Oxidase interaction as molecular basis of Schizophrenia.	132
Investigating the molecular basis of schizophrenia: the effect of pLG72 interaction on the functionality of human D-amino acid oxidase	132
Modulation of the oxygen affinity of D-amino acid oxidase: production of evolved variants for a cancer enzyme	131
Engineering the substrate specificity of D-amino acid oxidase: a directed evolution approach	130
Enzyme factory: engineering of new biocatalysts strating from a common scaffold.	130
Modulation of the oxygen affinity of D-amino acid oxidase: production of evolved variants for a cancer enzyme therapy	130
Combinatorial and computational challenges to design the substrate specificity of D-amino acid oxidase	130
Reaction mechanism of glycine oxidase, a new flavoenzyme active on glycine	129
Studies on the elimination reaction of Rhodotorula gracilis D-amino acid oxidase with beta-chloro-D-alanine	129
Kinetic mechanism of glycine oxidase	129
Structure-function relationships in glycine oxidase from Bacillus subtilis	127
Structure-function correlation in glycine oxidase from Bacillus subtilis	127
Cholesterol oxidase from Brevibacterium sterolicum - The relationship between covalent flavinylation and redox properties	125
In vivo studies on the D-amino acid oxidase-pLG72 interaction in human brain	125
Engineering the substrate specificity of D-amino acid oxidase by rational and irrational design	124
Engineering a new D-amino acid oxidase: an evoluted enzyme and its applications	124
Role of the C-terminal portion of yeast D-amino acid oxidase in stability and in aggregation state	124
Structure and function of Rhodotorula gracilis D-amino acid oxidase: site-directed mutagenesis of arginine 285	124
Investigating D-Amino Acid Oxidase and pLG72 as potential targets of the antipsychotic drug chlorpromazine.	124
Glycine oxidase from Bacillus subtilis: role of histidine 244 and methionine 261	124
On the oxygen reactivity of flavooxidase	124
Engineering the D-amino acid oxidase from Rhodotorula gracilis to facilitate its downstream processing	123
Investigation of the oxygen reactivity if D-amino acid oxidase: production of evolved variants for gene therapy.	123
Novel drugs for schizophrenia treatment: the mechanism of human D-amino acid oxidase inhibition	123
Thermal stability of yeast D-amino acid oxidase: Deconvoluting the contributions of the dimeric aggregation state	122
Role of the beta12-beta13 loop of yeast D-amino acid oxidase on stability and on aggregation: a rational design and thermodynamic study	120
Reaction mechanism of flavin dehydrogenation by D-amino acid oxidase	120
Rational design of a novel specificity of D-amino acid oxidase: towards the biosensor for all D-amino acids?	120
Very high resolution crystal structure of D-amino Acid oxidase. Insights into the reaction mechanism and mode of ligand binding	120
Reaction mechanism of glycine oxidase, a new flavoenzyme active on glycine	119
Techniques for the engineering of D-amino acid oxidase substrate specificity	118
Totale	15.163

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Categoria	#
all - tutte	82.538
article - articoli	0
book - libri	0
conference - conferenze	0
curatela - curatele	0
other - altro	0
patent - brevetti	0
selected - selezionate	0
volume - volumi	0
Totale	82.538

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	Totale	Lug	Ago	Sett	Ott	Nov	Dic	Gen	Feb	Mar	Apr	Mag	Giu
2020/2021	297	0	0	0	0	0	0	0	0	0	0	0	297
2021/2022	1.383	157	183	157	92	58	19	64	87	78	189	104	195
2022/2023	2.069	183	96	160	229	164	478	0	308	283	54	60	54
2023/2024	3.794	655	655	662	656	726	211	11	33	88	23	15	59
2024/2025	2.048	12	17	402	52	64	144	65	171	217	203	149	552
2025/2026	5.099	375	256	125	668	569	329	1.167	354	560	370	212	114
Totale													20.823